Clinical observation of conscious sedation and bronchoscopy in AECOPD patients with respiratory failure

Corresponding author: 王盛龙, liuzhouribao@163.com

DOI: 10.12201/bmr.202608.00040

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  Abstract: Objective Observing the clinical effect of conscious sedation bronchoscopy in patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) complicated with respiratory failure. Methods From July 2021 to June 2023, 90 AECOPD patients with type I/II respiratory failure undergoing bronchoscopy at Liuzhou Traditional Chinese Medicine Hospital were randomly divided into local, conscious sedation, and general anesthesia groups (30 each). The local group received only lidocaine; the conscious sedation group received midazolam and fentanyl for a Ramsay score of 2-4; the general group received the same for a score of 5-6. HR, MAP, and SPO2 were monitored at T0 (pre-anesthesia), T1 (glottis insertion), T2 (BALF collection), and T3 (15 min post-op). pH, PaO2, and PCO2 were recorded at T0 and T3. Results No significant differences in HR, MAP, and SpO2 were observed between conscious and deep sedation at any time point (P>0.05), while significant differences were found between conscious sedation and local anesthesia at T1 and T2 (P<0.05). At T3, PaO2 differed significantly between conscious sedation and local anesthesia (P<0.05), and PaCO2 differed significantly between conscious and deep sedation (P<0.05). Conclusion For AECOPD patients with respiratory failure, bronchoscopy under conscious sedation reduces pain, improves comfort, minimizes respiratory depression from general anesthetics, and lowers CO2 retention, warranting clinical use.

  Key words: Conscious sedation; Bronchoscopy; Acute Exacerbation Of Chronic Obstructive Pulmonary disease; Respiratory Failure

  Submit time: 20 August 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-07-01	10.12201/bmr.202608.00040V1	Download

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