Modern Biological Interpretation of Traditional Chinese Medicine Syndromes:Insights into Inflammation–Cancer Transformation in Gastric Precancerous Lesions from the Perspective of Spleen–Stomach Dampness-Heat Syndrome

Corresponding author: HUANG Xuekuan, xkhuang2002@126.com

DOI: 10.12201/bmr.202606.00059

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  Abstract: Precancerous lesions of gastric cancer (PLGC) represent a critical stage in the development and progression of gastric cancer. Their progression is closely associated with persistent chronic inflammation, gastric microbiota dysbiosis, metabolic reprogramming, and epigenetic abnormalities. Spleen–stomach dampness-heat syndrome is one of the common traditional Chinese medicine syndrome patterns observed in patients with PLGC, and is frequently associated with Helicobacter pylori infection, gastric mucosal inflammatory activity, intestinal metaplasia, and other pathological changes. Modern studies suggest that spleen–stomach dampness-heat syndrome may correspond to a pathological state characterized by a pro-inflammatory microenvironment, increased metabolic burden, and microbiota dysbiosis. It may participate in gastric mucosal inflammation–cancer transformation through immune-inflammatory imbalance, metabolic abnormalities, and molecular regulatory alterations. This article reviews the mechanisms underlying the association between spleen–stomach dampness-heat syndrome and inflammation–cancer transformation in PLGC from the perspectives of gastric microbiota, immune inflammation, metabolic reprogramming, and epigenetic regulation, aiming to provide a reference for syndrome-based stratification and interventions based on clearing heat and resolving dampness in PLGC.

  Key words: Gastric precancerous lesions; Spleen–stomach dampness-heat syndrome; Inflammation–cancer transformation; Inflammatory microenvironment; Traditional Chinese medicine

  Submit time: 19 June 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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