Advance in research on the prevention and treatment of gastric cancer by Traditional Chinese Medicine through modulation of programmed cell death

Corresponding author: YANG Jiaqi, pkuyangjiaqi@bjmu.edu.cn

DOI: 10.12201/bmr.202512.00063

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  Abstract: Gastric cancer ranks among the most prevalent malignancies in China, necessitating targeted interventions as a crucial strategy for its prevention and treatment. Programmed cell death (PCD) plays a pivotal role in maintaining organismal homeostasis and regulating tumor initiation and progression, thereby possessing significant research and translational potential. This review systematically examines recent advancements in the prevention and treatment of gastric cancer through traditional Chinese medicine (TCM), focusing on the modulation of PCD modalities such as apoptosis, ferroptosis, pyroptosis, and autophagy. Current evidence suggests that TCM exerts anti-cancer effects by modulating PCD-related pathways through integrated actions involving multiple components, targets, and signaling networks. While the majority of existing evidence is derived from in vitro and in vivo experimental studies, and clinical evidence requires further substantiation, TCM has demonstrated distinct advantages and promising potential in the prevention and treatment of gastric cancer via PCD regulation. Future research should employ advanced scientific and technological methodologies to elucidate the underlying molecular mechanisms and undertake higher-quality clinical investigations. This approach will contribute to a more robust theoretical foundation and offer practical guidance for individualized therapy and the development of novel drugs for gastric cancer.

  Key words: Traditional Chinese medicine; Programmed cell death; Gastric cancer

  Submit time: 21 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-12-01	10.12201/bmr.202512.00063V1	Download

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