Mechanism of HIF-1 Signaling Pathway in Obstructive Sleep Apnea and Current Research Status of Traditional Chinese Medicine Interventions

Corresponding author: Zhang Aihua, kmzahys@126.com

DOI: 10.12201/bmr.202512.00021

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  Abstract: Obstructive sleep apnea (OSA) is a prevalent sleep disorder that significantly impairs patients quality of life and overall health. With in-depth research into the pathogenesis of OSA, the hypoxia-inducible factor-1 (HIF-1) signaling pathway has been identified as closely associated with its pathophysiological processes. Aberrant expression of the HIF-1 signaling pathway can influence the progression of OSA through multiple mechanisms, including the regulation of oxidative stress, inflammatory responses, and metabolic disorders. In recent years, traditional Chinese medicine (TCM), as a conventional and effective therapeutic approach, has been gradually introduced into OSA treatment research. TCM alleviates clinical symptoms in OSA patients by modulating the HIF-1 signaling pathway, thereby improving oxidative stress and inflammatory responses associated with OSA. This article aims to elucidate the mechanistic role of the HIF-1 signaling pathway in OSA, summarize recent advancements in TCM research through the regulation of the HIF-1 signaling pathway, and explore its clinical application prospects, thereby providing novel insights and directions for the comprehensive treatment of OSA.

  Key words: Traditional Chinese Medicine; HIF-1 signaling pathway; Obstructive sleep apnea; Research progress.

  Submit time: 9 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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