通讯作者: 张爱华, kmzahys@126.com

DOI：10.12201/bmr.202512.00021

Mechanism of HIF-1 Signaling Pathway in Obstructive Sleep Apnea and Current Research Status of Traditional Chinese Medicine Interventions

• 摘要：阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是一种常见的睡眠障碍性疾病，严重影响患者的生活质量和整体健康。随着对OSA发病机制的深入研究，缺氧诱导因子-1 (hypoxia inducible factor-1，HIF-1)信号通路被发现与其病理生理过程密切相关。HIF-1信号通路的异常表达可通过调控氧化应激、炎症反应、代谢紊乱等多条路径影响OSA的进程。近年来，中医药作为一种传统而有效的治疗手段，逐渐被引入到OSA的治疗研究中。中医药通过调节HIF-1信号通路，改善OSA的氧化应激、炎症反应等，减轻OSA患者的临床症状。本文旨在阐述HIF-1信号通路在OSA中的作用机制，总结近年来中医药通过调控HIF-1信号通路研究进展，探讨其临床应用前景，为OSA的综合治疗提供新的思路与方向。

  关键词： HIF-1信号通路；阻塞性睡眠呼吸暂停；作用机制；中医药; ; ; 

   

  Abstract: Obstructive sleep apnea (OSA) is a prevalent sleep disorder that significantly impairs patients quality of life and overall health. With in-depth research into the pathogenesis of OSA, the hypoxia-inducible factor-1 (HIF-1) signaling pathway has been identified as closely associated with its pathophysiological processes. Aberrant expression of the HIF-1 signaling pathway can influence the progression of OSA through multiple mechanisms, including the regulation of oxidative stress, inflammatory responses, and metabolic disorders. In recent years, traditional Chinese medicine (TCM), as a conventional and effective therapeutic approach, has been gradually introduced into OSA treatment research. TCM alleviates clinical symptoms in OSA patients by modulating the HIF-1 signaling pathway, thereby improving oxidative stress and inflammatory responses associated with OSA. This article aims to elucidate the mechanistic role of the HIF-1 signaling pathway in OSA, summarize recent advancements in TCM research through the regulation of the HIF-1 signaling pathway, and explore its clinical application prospects, thereby providing novel insights and directions for the comprehensive treatment of OSA.

  Key words: Traditional Chinese Medicine; HIF-1 signaling pathway; Obstructive sleep apnea; Research progress.

  提交时间：2025-12-09

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-11-23	10.12201/bmr.202512.00021V1	下载

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