通讯作者: 杨佳启, pkuyangjiaqi@bjmu.edu.cn

DOI：10.12201/bmr.202512.00063

Advance in research on the prevention and treatment of gastric cancer by Traditional Chinese Medicine through modulation of programmed cell death

• 摘要：胃癌是我国高发的恶性肿瘤之一，靶向干预是其防治的重要策略。程序性细胞死亡（programmed cell death, PCD）是维持机体稳态并参与肿瘤发生发展调控的关键环节，具有重要的研究与转化价值。本文系统综述了中医药通过调控凋亡、铁死亡、焦亡和自噬等PCD防治胃癌的研究进展。现有研究表明，中医药能够通过多成分、多靶点、多通路的综合调控作用，干预PCD相关通路，从而实现抗癌效应。尽管目前相关证据多来自体内外实验，临床证据仍有待进一步完善，但中医药在调控PCD以防治胃癌方面已展现出独特优势与广阔前景。未来应结合现代科学技术深入阐明其分子机制，并开展更高质量的临床研究，以期为胃癌个体化治疗与新药研发提供更坚实的理论依据与实践指导。

  关键词： 中医药; 胃癌; 程序性细胞死亡

   

  Abstract: Gastric cancer ranks among the most prevalent malignancies in China, necessitating targeted interventions as a crucial strategy for its prevention and treatment. Programmed cell death (PCD) plays a pivotal role in maintaining organismal homeostasis and regulating tumor initiation and progression, thereby possessing significant research and translational potential. This review systematically examines recent advancements in the prevention and treatment of gastric cancer through traditional Chinese medicine (TCM), focusing on the modulation of PCD modalities such as apoptosis, ferroptosis, pyroptosis, and autophagy. Current evidence suggests that TCM exerts anti-cancer effects by modulating PCD-related pathways through integrated actions involving multiple components, targets, and signaling networks. While the majority of existing evidence is derived from in vitro and in vivo experimental studies, and clinical evidence requires further substantiation, TCM has demonstrated distinct advantages and promising potential in the prevention and treatment of gastric cancer via PCD regulation. Future research should employ advanced scientific and technological methodologies to elucidate the underlying molecular mechanisms and undertake higher-quality clinical investigations. This approach will contribute to a more robust theoretical foundation and offer practical guidance for individualized therapy and the development of novel drugs for gastric cancer.

  Key words: Traditional Chinese medicine; Programmed cell death; Gastric cancer

  提交时间：2025-12-21

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 陈新潮, 李灵冰, 陈曦. 中药单体在胃癌前病变中的研究进展. 2025. doi: 10.12201/bmr.202511.00037

  胡张琴, 李东芳. 基于“瘀-毒-虚”理论治疗老年性胃癌的经验. 2025. doi: 10.12201/bmr.202509.00069

  朱林, 蒋涛. 中医药调控相关信号通路治疗膝骨关节炎的研究进展. 2025. doi: 10.12201/bmr.202509.00021

  徐静雯, 朱彦. 中医药领域本体研究现状. 2022. doi: 10.12201/bmr.202207.00006

  陈昕, 杨晓彤, 李一凡, 纪伟. 中医药防治干燥综合征的可视化分析. 2025. doi: 10.12201/bmr.202502.00032

  庄旭颉, 高丽丽. 基于NLRP3信号通路探究中医药靶治疗缺血性脑卒中的研究进展. 2025. doi: 10.12201/bmr.202509.00056

  胡铁骊, 周博翔, 于浩. 中医药数据资源目录体系的构建与研究. 2023. doi: 10.12201/bmr.202312.00025

  叶凤琴, 王明刚, 罗娟, 莫征远, 陈鑫鑫, 王秀峰. 免疫细胞与中医药在慢加急性肝衰竭中的作用. 2025. doi: 10.12201/bmr.202504.00030

  刘金梅, 周太, 郑青. 试论“文化传承”视域下中医药文化的连续性. 2024. doi: 10.12201/bmr.202412.00013

  王燕, 段凌志, 禹映萍, 李慧敏, 王祥, 张爱华. HIF-1信号通路在阻塞性睡眠呼吸暂停中的作用机制及中医药干预研究现状. 2025. doi: 10.12201/bmr.202512.00021

• 序号	提交日期	编号	操作
  1	2025-12-01	10.12201/bmr.202512.00063V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论