通讯作者: 黄学宽, xkhuang2002@126.com

DOI：10.12201/bmr.202606.00059

Modern Biological Interpretation of Traditional Chinese Medicine Syndromes:Insights into Inflammation–Cancer Transformation in Gastric Precancerous Lesions from the Perspective of Spleen–Stomach Dampness-Heat Syndrome

• 摘要：胃癌前病变（precancerous lesions of gastric cancer，PLGC）是胃癌防治的重要窗口，其进展涉及慢性炎症、胃微生态失衡、代谢重编程及表观遗传异常。脾胃湿热证在PLGC及相关癌前状态中占有一定比例，并与幽门螺杆菌（Helicobacter pylori，Hp）感染、胃黏膜炎症及糜烂等表现相关。现有研究提示，该证候与促炎状态、微生态和代谢异常可能相关，但缺乏证候特异性生物标志物证据。本文从胃微生态、炎症免疫、代谢重编程和表观遗传调控等方面综述相关研究，并分析证据局限，为证候客观化及清热化湿干预研究提供参考。

  关键词： 胃癌前病变; 脾胃湿热证; 炎–癌转化; 炎症微环境; 胃癌

   

  Abstract: Precancerous lesions of gastric cancer (PLGC) represent a critical stage in the development and progression of gastric cancer. Their progression is closely associated with persistent chronic inflammation, gastric microbiota dysbiosis, metabolic reprogramming, and epigenetic abnormalities. Spleen–stomach dampness-heat syndrome is one of the common traditional Chinese medicine syndrome patterns observed in patients with PLGC, and is frequently associated with Helicobacter pylori infection, gastric mucosal inflammatory activity, intestinal metaplasia, and other pathological changes. Modern studies suggest that spleen–stomach dampness-heat syndrome may correspond to a pathological state characterized by a pro-inflammatory microenvironment, increased metabolic burden, and microbiota dysbiosis. It may participate in gastric mucosal inflammation–cancer transformation through immune-inflammatory imbalance, metabolic abnormalities, and molecular regulatory alterations. This article reviews the mechanisms underlying the association between spleen–stomach dampness-heat syndrome and inflammation–cancer transformation in PLGC from the perspectives of gastric microbiota, immune inflammation, metabolic reprogramming, and epigenetic regulation, aiming to provide a reference for syndrome-based stratification and interventions based on clearing heat and resolving dampness in PLGC.

  Key words: Gastric precancerous lesions; Spleen–stomach dampness-heat syndrome; Inflammation–cancer transformation; Inflammatory microenvironment; Traditional Chinese medicine

  提交时间：2026-06-19

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2026-05-28	10.12201/bmr.202606.00059V1	下载

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