通讯作者: 廖凯明, 962597898@qq.com

DOI：10.12201/bmr.202604.00037

Clinical Observation of Xianglian Pills in Treating Chronic Atrophic Gastritis with Spleen-Stomach Damp-Heat Pattern Complicated by Helicobacter pylori Infection

• 摘要：目的 研究香连丸联合四联疗法治疗脾胃湿热型慢性萎缩性胃炎合并幽门螺杆菌感染的临床效果。方法 将80例脾胃湿热证CAG合并Hp感染的患者随机分为对照组和观察组，每组各40例。对照组予四联疗法联合叶酸片治疗，观察组予四联疗法联合香连丸治疗，其中叶酸片及香连丸治疗疗程均为16周，四联疗法疗程均为2周。比较两组治疗前后的胃镜病理积分、中医症状积分、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ及胃泌素17的变化情况，并记录Hp根除情况、不良反应发生情况。结果 两组治疗后胃镜病理积分、中医症状积分均较治疗前下调(P<0.05)，PGⅠ、G-17水平均较治疗前明显升高(P<0.05)，PGⅡ水平均较治疗前明显降低(P<0.05)，其中观察组在胃镜病理积分及中医症状积分改善程度方面优于对照组(P<0.05)，在提升PGⅠ、G-17水平及降低PGⅡ水平方面优于对照组(P<0.05)。比较两组患者治疗后的Hp根除情况，差异有统计学意义(P<0.05)。结论 香连丸治疗脾胃湿热型CAG合并Hp感染有良好的临床疗效，可促进胃黏膜病理修复，缓解症状，改善胃内环境，调节胃蛋白酶原及胃泌素水平，有较高的安全性。

  关键词： 香连丸；慢性萎缩性胃炎；幽门螺杆菌感染；脾胃湿热型；临床观察; ; ; ; 

   

  Abstract: Objective To investigate the clinical efficacy of Xianglian Pills combined with quadruple therapy in treating chronic atrophic gastritis (CAG) with spleen-stomach damp-heat pattern complicated by Helicobacter pylori (Hp) infection. Methods Eighty patients with CAG complicated by Hp infection and presenting spleen-stomach damp-heat syndrome were randomly assigned to a control group and an observation group, each comprising 40 patients. The Western medicine group received quadruple therapy combined with folic acid tablets, while the Chinese medicine group received quadruple therapy combined with Xianglian Pills. Both folic acid tablets and Xianglian Pills were administered for 16 weeks, and quadruple therapy was administered for 2 weeks. Comparisons were made between the two groups regarding changes in gastroscopic pathological scores, TCM symptom scores, pepsinogen I (PGⅠ), pepsinogen II (PGⅡ), and gastrin-releasing peptide 17 (G-17) before and after treatment. Hp eradication rates and adverse reaction occurrences were also recorded. Results Post-treatment gastroscopic pathology scores and TCM symptom scores decreased significantly in both groups compared to pre-treatment levels (P<0.05). PGⅠ and G-17 levels significantly increased (P<0.05), while PGⅡ levels significantly decreased (P<0.05) compared to pre-treatment levels. The observation group demonstrated superior improvement in endoscopic pathology scores and TCM symptom scores compared to the Western medicine group (P<0.05), and superior elevation of PGⅠ and G-17 levels alongside reduction of PGⅡ levels (P<0.05). Comparison of Hp eradication rates between groups after treatment revealed statistically significant differences (P<0.05). Conclusion Xianglianwan demonstrates favorable clinical efficacy in treating spleen-stomach damp-heat pattern CAG with Hp infection. It promotes gastric mucosal pathological repair, alleviates symptoms, improves gastric microenvironment, regulates pepsinogen and gastrin levels, and exhibits high safety.

  Key words: Xianglian Pills; Chronic Atrophic Gastritis; Helicobacter pylori Infection; Damp-Heat in Spleen and Stomach Pattern; Clinical Observation

  提交时间：2026-04-07

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• 序号	提交日期	编号	操作
  1	2026-03-12	10.12201/bmr.202604.00037V1	下载

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