通讯作者: 张杨, yangzhang83@163.com

DOI：10.12201/bmr.202604.00181

Research Progress on the Mechanisms of Panax notoginseng and Its Active Components Against Gastric Cancer and Gastric Precancerous Lesions.HOU Qingli, YANG Linglong, WU Lili, HUANG Guoxin, WANG Jingbin, ZHANG Yang

• 摘要：胃“炎-癌”转化是一个动态病理演变过程，由胃癌前病变转化为胃癌。胃癌前病变包括萎缩、肠上皮化生及异型增生等，防治胃癌前病变可以有效降低胃癌的发病率。现代药理学研究表明，中药三七的主要活性成分如皂苷类、黄酮类等可通过多种途径抑制“炎-癌”转化，包括抑制细胞异常增殖、诱导凋亡，调节自噬，减轻炎症反应、修复胃黏膜屏障，抗氧化应激及抑制血管生成，体现多靶点、多通路、多层次的作用特点。目前关于三七抗胃“炎-癌”转化的现有机制研究多在于细胞方面，动物相关实验和临床具体研究明显不足，且除三七皂苷类成分外，其他活性成分抗胃“炎-癌”转化机制研究较少，同时各信号通路间的交互调控网络尚未阐明，成分-靶点-通路的系统研究待开展。本文将通过梳理近年来三七抗胃“炎-癌”转化的有效成分及机制，提供相关理论依据。

  关键词： 三七; “炎-癌”转化; 胃癌; 胃癌前病变; 作用机制; 研究进展

   

  Abstract: Gastric precancerous lesions are critical pathological stages in the progression from normal gastric mucosa to gastric cancer, including atrophy, intestinal metaplasia, and dysplasia. Preventing and treating gastric precancerous lesions can effectively reduce the incidence of gastric cancer. Modern pharmacological research indicates that the main active components of the traditional Chinese medicine Panax notoginseng, such as saponins and flavonoids, can inhibit the progression of gastric precancerous lesions and treat gastric cancer through multiple pathways. These mechanisms include inhibiting abnormal cell proliferation, inducing apoptosis, regulating autophagy, alleviating inflammatory responses, repairing the gastric mucosal barrier, combating oxidative stress, and inhibiting angiogenesis, demonstrating characteristics of multi-target, multi-pathway, and multi-level actions. Current research on the mechanisms of Panax notoginseng against gastric cancer and gastric precancerous lesions is mostly focused at the cellular level, with significant deficiencies in animal-related experiments and specific clinical studies. Furthermore, besides notoginseng saponins, there is limited research on the mechanisms of other active substances such as polysaccharides and flavonoids against gastric cancer and gastric precancerous lesions. Meanwhile, the interactive regulatory network among various signaling pathways has not yet been elucidated, and systematic research on component-target-pathway interactions urgently needs to be conducted. This article reviews the active components and mechanisms of Panax notoginseng against gastric cancer and gastric precancerous lesions in recent years, aiming to provide relevant theoretical foundations for deepening research in this field.

  Key words: Panax notoginseng; Active components; Gastric cancer; Gastric precancerous lesions; Mechanism of action; Research progress

  提交时间：2026-04-30

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 陈新潮, 李灵冰, 陈曦. 中药单体在胃癌前病变中的研究进展. 2025. doi: 10.12201/bmr.202511.00037

  程悦, 郝小鹰. 胃泌素在胃癌前病变中的临床研究进展. 2025. doi: 10.12201/bmr.202502.00030

  杨欣彤, 纪云西. 蛋白泛素化修饰在胃癌发生发展中作用的研究进展. 2026. doi: 10.12201/bmr.202601.00012

  郝雅琴, 胡云峰, 郝静, 赵鑫. 环状RNA与自噬在胃癌中作用的研究进展. 2023. doi: 10.12201/bmr.202304.00001

  王 曜, 徐陆周. 基于“痞坚之处,必有伏阳”理论探讨胃“炎癌转化”的病机及治疗思路. 2025. doi: 10.12201/bmr.202511.00044

  王耀强, 汪浩浩, 罗长江. HMGB1在胃癌进展和治疗中的作用. 2024. doi: 10.12201/bmr.202412.00009

  郑中兴, 杨佳启, 崔彦. 中医药调控程序性细胞死亡防治胃癌的研究进展. 2025. doi: 10.12201/bmr.202512.00063

  高梦雅, 张谦. 中药活性成分干预脓毒症炎症反应通路的研究进展. 2026. doi: 10.12201/bmr.202602.00025

  沈思齐, 吴璐瑶, 方豪祥, 邵燕飞. 黄酮类化合物在肾病综合征防治中的作用机制与研究进展. 2025. doi: 10.12201/bmr.202511.00086

  赵丽媛, 陈志芳. PAX1甲基化在宫颈癌中诊断及分流作用的研究进展. 2024. doi: 10.12201/bmr.202412.00067

• 序号	提交日期	编号	操作
  1	2026-03-23	10.12201/bmr.202604.00181V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论