通讯作者: 邵燕飞, shaoyanfei3@sina.com

DOI：10.12201/bmr.202511.00086

Mechanism and research progress of flavonoids in prevention and treatment of nephrotic syndrome

• 摘要：本综述系统阐述了黄酮类化合物在肾病综合征防治中的多靶点作用机制与研究进展，指出其通过抗氧化、抗炎、免疫调节及抗凋亡等多种途径发挥肾脏保护作用，代表性成分如槲皮素、大豆异黄酮、芹菜素和木犀草素等在实验研究中显示出减轻蛋白尿、改善足细胞损伤与调节脂代谢的潜力，同时总结了原花青素B2、淫羊藿苷和毛蕊异黄酮等新型黄酮在修复滤过屏障、抑制焦亡与上皮-间质转化等方面的机制进展；尽管现有证据多源于动物与细胞实验，临床转化仍面临生物利用度低、机制研究碎片化及高质量临床试验缺乏等挑战，未来需借助药剂学改良、多中心临床研究及联合治疗策略进一步推动其作为NS辅助干预药物的应用前景。

   

  Abstract: This review systematically elaborates on the multi-target mechanisms and research progress of flavonoids in the prevention and treatment of Nephrotic Syndrome (NS), highlighting their renal protective effects through antioxidant, anti-inflammatory, immunomodulatory, and anti-apoptotic pathways. Representative compounds such as quercetin, soybean isoflavones, apigenin, and luteolin have demonstrated potential in experimental studies to alleviate proteinuria, ameliorate podocyte injury, and regulate lipid metabolism. Furthermore, the review summarizes recent advances on novel flavonoids like procyanidin B2, icariin, and calycosin, detailing their roles in repairing the filtration barrier, inhibiting pyroptosis, and suppressing epithelial-mesenchymal transition. Although current evidence is largely derived from animal and cellular studies, clinical translation faces challenges such as low bioavailability, fragmented mechanistic understanding, and a lack of high-quality clinical trials. Future efforts should focus on pharmaceutical improvements, multi-center clinical research, and combination therapy strategies to advance the application of flavonoids as adjuvant therapeutic agents for NS.

  提交时间：2025-11-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-11-13	10.12201/bmr.202511.00086V1	下载

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