Early Clinical Efficacy Study of Hyperbaric Oxygen Therapy for Acute Ischemic Stroke

Corresponding author: xiongxiaoping

DOI: 10.12201/bmr.202605.00064

•  

  Abstract: 【】 Objective? To assess the early outcomes and safety of adding hyperbaric oxygen therapy for acute ischemic stroke patients who present between 12 and 24 hours after symptom onset. Methods? A total of 100 eligible patients with acute ischemic stroke were randomly assigned to a control group (n=50) receiving standard medical management or an observation group (n=50) receiving standard management plus hyperbaric oxygen therapy. Neurological function, disability level, and activities of daily living were assessed using the Activities of Daily Living scale, modified Rankin Scale, and National Institutes of Health Stroke Scale before treatment and at 30 days post-treatment. Adverse events were recorded throughout the treatment period. Results The treatment group exhibited a higher overall effective rate after 30 days of treatment (94.0%, 47/50), which was significantly superior to that of the control group (80.0%, 40/50) (χ2=13.539, P=0.004). No significant between-group differences were observed at baseline (P>0.05). After 30 days of treatment, the study group showed lower NIHSS scores (1.9±1.7 vs. 4.4±5.1), lower mRS scores (0.9±0.7 vs. 1.6±1.1), and higher ADL scores (89.1±12.1 vs. 81.1±17.3) compared with the control group (P<0.01 or P<0.05). There was no statistically significant discrepancy between the two groups regarding adverse event incidence (χ2=2.041, P=0.153). Conclusion? Adding hyperbaric oxygen therapy to standard internal medicine treatment can further enhance early neurological recovery in patients with acute ischemic stroke within 12 to 24 hours of onset, without introducing additional safety concerns.

  Key words: Hyperbaric oxygen; Acute ischemic stroke; Neuroprotection; Time window; Clinical efficacy

  Submit time: 18 May 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• SHEN Yueling, CAI Yamei. Evaluation of the implementation effect of TCM clinical pathway optimization scheme for acute ischemic stroke with wind-phlegm stasisZhang Peng, SHEN Yueling, CAI Yame. 2025. doi: 10.12201/bmr.202511.00005

  Yang min. Study on the Treatment of Coagulation Dysfunction and Limb Swelling after Bloodborne Venom Snake Bite with Hyperbaric Oxygen Combined with External Use of Snake Damage Powder. 2024. doi: 10.12201/bmr.202407.00060

  liqiqi, wangshangshu, haoxijun, guoquanrong. A Study on the Influencing Factors of Rehabilitation Outcomes in Patients with Acute Ischemic Stroke Complicated with Hypertension　LI Youfan1,LI Qiqi1,WANG Shangshu2,HAO Xijun1*,GUO Quanrong1. 2025. doi: 10.12201/bmr.202510.00047

  DENG Guifang, LI Siwei, CHENG Fengying, ZHANG Ying, CHANG Huili. Evaluation of the Effect of Clinical Pharmacist Pharmaceutical Science Popularization Intervention on Secondary Prevention in Patients with Ischemic Stroke. 2026. doi: 10.12201/bmr.202603.00094

  Pei wenjuan, Tang Yubin, Zhang yanyang. Research Progress on the Role of Exosomes in the Diagnosis and Treatment of Ischemic Stroke. 2026. doi: 10.12201/bmr.202603.00118

  An Hongwei, Wang Ruixin. The potential value of LncRNA MALAT1 in the treatment of ischemic stroke. 2025. doi: 10.12201/bmr.202506.00007

  xu junjie, gao yang, xu yunfeng, wang baoxiang, hu jin. Imaging factor analysis of reversible ischemic lesionin cranial CT after mechanical thrombectomy for acute anterior circulation large vessel occlusion. 2025. doi: 10.12201/bmr.202503.00006

  WANG KAI HUA, QIN SHE HUAN, HE SI JIA, YANG MAN CHUN, SU GUI LAN. Advances in Understanding the Role of Klotho Protein in Ischemic Stroke. 2026. doi: 10.12201/bmr.202603.00114

  HE Sijia. Research Progress on the Relationship between Cystatin C and Ischemic Stroke. 2025. doi: 10.12201/bmr.202511.00036

  hanxuan, caili. Advances in the application of carotid ultrasound in assessing the risk of ischemic vascular diseases. 2025. doi: 10.12201/bmr.202510.00060

• ID	Submit time	Number	Download
  1	2026-04-29	10.12201/bmr.202605.00064V1	Download

• Public  Anonymous  To author only Submit Comments