Research Progress on the Relationship between Cystatin C and Ischemic Stroke

DOI: 10.12201/bmr.202511.00036

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  Abstract: Cystatin C is a potent cysteine protease inhibitor that plays a critical role in multiple biological processes. In recent years, a growing body of evidence has demonstrated a close association between CysC and the pathogenesis of ischemic stroke, suggesting its potential as a biomarker for predicting the risk and prognosis of this condition. Nevertheless, the specific mechanism of CysC in ischemic stroke has not been fully elucidated yet, and it may be related to pathways such as vascular endothelial cell homeostasis, inflammatory response, oxidative stress, autophagy and synaptic structure. This review aims to synthesize current knowledge on the potential mechanisms of CysC in ischemic stroke, thereby offering a theoretical foundation for its translational exploration as a novel therapeutic target.

  Key words: cystatin C; ischemic stroke; mechanism

  Submit time: 13 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-11-16	10.12201/bmr.202511.00036V1	Download

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