A Study on the Influencing Factors of Rehabilitation Outcomes in Patients with Acute Ischemic Stroke Complicated with Hypertension　LI Youfan1,LI Qiqi1,WANG Shangshu2,HAO Xijun1*,GUO Quanrong1

Corresponding author: haoxijun, 723375698@qq.com

DOI: 10.12201/bmr.202510.00047

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  Abstract: Objective　To investigate the impact of early impairment in different cognitive domains on rehabilitation outcomes in patients with acute ischemic stroke (AIS) and hypertension. Methods　A prospective cohort study was conducted, consecutively enrolling 280 AIS patients with hypertension from the Affiliated Hospital of North China University of Science and Technology and the Kailuan General Hospital between August and December 2024. Within 72 hours of stroke onset, cognitive function was assessed using domain scores of the Montreal Cognitive Assessment (MoCA), and stroke severity was measured using the National Institutes of Health Stroke Scale (NIHSS) score. Rehabilitation outcome was evaluated at the 3-month follow-up using the Glasgow Outcome Scale-Extended (GOS-E, score range 1-8). Data analysis employed Spearman rank correlation, Mann-Whitney U test, and multiple linear regression. Results　Multiple linear regression analysis revealed that hypertension grade (β = -0.093, P < 0.05), NIHSS total score (β = -0.278, P < 0.001), MoCA language domain score (β = 0.299, P < 0.001), and MoCA abstraction domain score (β = 0.170, P < 0.05) were independent influencing factors of rehabilitation outcomes in AIS patients with hypertension. Conclusion　Early impairment in the language and abstraction cognitive domains significantly affects rehabilitation outcomes in AIS patients with hypertension.

  Key words: Acute ischemic stroke，Hypertension， Cognitive function， Rehabilitation outcomes，Influencing factors

  Submit time: 26 October 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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