Study on the Treatment of Coagulation Dysfunction and Limb Swelling after Bloodborne Venom Snake Bite with Hyperbaric Oxygen Combined with External Use of Snake Damage Powder

Corresponding author: Yang min, zyyangmin@126.com

DOI: 10.12201/bmr.202407.00060

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  Abstract: Objective Study on the therapeutic effect of hyperbaric oxygen combined with snake venom powder on coagulation dysfunction and limb swelling caused by bloodline venomous snake bites. Methods 112 patients with blood circulation venomous snake bites admitted to our hospital from April 2021 to October 2023 were randomly divided into a conventional treatment group, a conventional treatment+snake bite powder treatment group, a conventional treatment+hyperbaric oxygen treatment group, and a conventional treatment+hyperbaric oxygen combined with snake bite powder treatment group. Each group included 28 patients. The conventional treatment group received conventional treatment, while the conventional treatment+snake bite powder treatment group received snake bite powder in addition to conventional treatment. The conventional treatment+hyperbaric oxygen treatment group received hyperbaric oxygen treatment in addition to conventional treatment. The conventional treatment+hyperbaric oxygen combined with snake bite powder treatment group received hyperbaric oxygen and snake bite powder external application treatment in addition to conventional treatment. Observe and compare the circumference difference, pain score changes, and coagulation function (prothrombin time, thromboplastin time, fibrinogen) levels between the affected limb and the healthy limb in four groups. Results All data in each group follow a normal distribution. For the comparison of weekly diameter difference, there was a statistically significant difference between the groups before and after self comparison (P<0.05). For the difference in circumference on the third day, there was a statistically significant difference (P<0.05) between the conventional treatment+hyperbaric oxygen combined with snake wound powder treatment group and the conventional treatment group, as well as the conventional treatment+snake wound powder treatment group. On the fifth day, there was a statistically significant difference in weekly diameter between the groups (P<0.05). Comparing the coagulation function (prothrombin time, thromboplastin time, fibrinogen) of each group after treatment, there was a statistically significant difference (P<0.05) between the conventional treatment group and the conventional treatment+hyperbaric oxygen treatment group in the conventional treatment+snake injury powder treatment group, and a statistically significant difference (P<0.05) between the conventional treatment+hyperbaric oxygen combined with snake injury powder treatment group and the other three groups. For VAS pain scores, there was a statistically significant difference between the groups before and after treatment (P<0.05), and between the groups after treatment (P<0.05). Conclusion Hyperbaric oxygen has advantages in treating swelling and pain in patients with venomous snake bites, while topical self formulated snake venom powder has more advantages in improving coagulation function. The combination of hyperbaric oxygen and topical self formulated snake venom powder has better therapeutic effects in improving coagulation function and limb swelling and pain.

  Key words: Venomous snake bite；hyperbaric oxygen；External snakebite powder

  Submit time: 24 July 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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