Research progress of Apelin in oral diseases

Corresponding author: Wang Qiang, wangqiang126email@126.com

DOI: 10.12201/bmr.202603.00040

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  Abstract: Apelin is an endogenous peptide that, as a ligand of its receptorputative receptor protein related to the angiotensin II type 1 receptor(APJ), plays a key role in numerous physiological and pathological processes. In recent years, studies have revealed the expression and function of Apelin in oral diseases, especially periodontitis and oral cancer, which has attracted extensive attention in the academic community. Apelin-13 has shown great application potential in dental pulp injury repair, repair of oral and maxillofacial deformities and defects, and bone integration of implants. This review summarizes and analyzes the research progress and application prospects of Apelin in the oral field, aiming to provide new perspectives for the research of Apelin in oral and systemic diseases, as well as theoretical support for Apelin to serve as a novel therapeutic target for oral diseases.

  Key words: Apelin；Apelin-13；Periodontitis; Oral cancer; Stem cell differentiation; Biomarkers.; ; 

  Submit time: 11 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-01-30	10.12201/bmr.202603.00040V1	Download

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