Research Progress on the traditional Chinese medicine Treatment of Inflammatory Diseases Based on the Cuproptosis

Corresponding author: WANG Jiajia, wjj8935@163.com

DOI: 10.12201/bmr.202601.00064

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  Abstract: Copper is an essential trace element, and its homeostatic imbalance can induce cuproptosis, a novel form of cell death discovered in recent years. Cuproptosis, primarily by interfering with the lipoylated components of the tricarboxylic acid (TCA) cycle, leads to toxic protein aggregation and mitochondrial stress. It has been closely implicated in the pathogenesis of various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease. As understanding of the cuproptosis mechanism deepens, Traditional Chinese Medicine (TCM), leveraging its multi-component and multi-target advantages, demonstrates unique potential in mitigating cuproptosis-related inflammatory responses. This article systematically reviews the mechanisms of cuproptosis in various inflammatory diseases and summarizes recent research progress on TCM interventions that modulate copper homeostasis, inhibit oxidative stress, and regulate immune inflammation. The review aims to provide a theoretical basis for elucidating TCMs mechanisms from the perspective of cuproptosis and to offer new insights and potential therapeutic targets for the clinical management of inflammatory diseases.

  Key words: cuproptosis; copper homeostasis; inflammatory diseases; traditional Chinese medicine

  Submit time: 21 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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