Exploring the Mechanism and Research Progress of Traditional Chinese Medicine in the Treatment of Chronic Hepatitis B Based on the MAPK Signaling Pathway

Corresponding author: dengxin, dx8848@126.com

DOI: 10.12201/bmr.202609.00008

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  Abstract: Hepatitis B virus (HBV) infection is a global public health issue that seriously threatens human health. Its pathogenesis is complex, and long-term progression can lead to liver fibrosis, cirrhosis, and even liver cancer. The mitogen-activated protein kinase (MAPK) signaling pathway plays a critical role in the initiation and progression of chronic hepatitis B (CHB), participating in various pathophysiological processes such as cell proliferation, apoptosis, and inflammatory responses. Traditional Chinese Medicine (TCM) offers unique advantages in the treatment of CHB. Numerous studies have shown that TCM can regulate the MAPK signaling pathway through multi-target and multi-pathway mechanisms, thereby exerting antiviral, anti-inflammatory, and anti-liver fibrosis effects. This article reviews the composition of the MAPK signaling pathway, its mechanism of action in CHB, and the research progress on the treatment of CHB with TCM via this pathway, aiming to provide new insights and a theoretical basis for the treatment of CHB.

  Key words: Hepatitis B; Traditional Chinese Medicine; Mitogen-activated protein kinase signaling pathway; Mechanism of action

  Submit time: 6 September 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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• ID	Submit time	Number	Download
  1	2026-05-24	10.12201/bmr.202609.00008V1	Download

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