Mechanisms and Clinical Research Progress of Zhenwu Decoction in the Treatment of Dilated Cardiomyopathy

Corresponding author: Li Zheng, goldkey_ren@sohu.com

DOI: 10.12201/bmr.202608.00043

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  Abstract: Dilated cardiomyopathy (DCM) is mainly characterized by left ventricular dilatation and impaired systolic function without abnormal loading factors, with poor long-term prognosis. Single Western medicine intervention has obvious limitations. In recent years, Zhenwu Decoction, a classic prescription of traditional Chinese medicine (TCM), has achieved remarkable curative effects in the treatment of DCM. By reviewing relevant literature, this paper elaborates on three aspects including TCM theoretical basis, pharmacological mechanisms and clinical research progress. It discusses its multi-target therapeutic effects through regulating cellular autophagy, inhibiting myocardial fibrosis, improving calcium homeostasis and other pathways, and verifies its clinical efficacy based on clinical studies. This paper aims to provide references for the integrated treatment of DCM with TCM and Western medicine, and boost the innovative development and clinical transformation of traditional Chinese medicine.

  Key words: Zhenwu Decoction; Dilated Cardiomyopathy; Warming Yang and Promoting Diuresis; Integrated Traditional Chinese and Western Medicine

  Submit time: 24 August 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-07-23	10.12201/bmr.202608.00043V1	Download

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