Clinical Efficacy and Quality of Life Evaluation of Integrated Traditional Chinese-Western Medicine Staging Therapy for Granulomatous Lobular Mastitis

Corresponding author: 王卿炜, wangqingwei@fjsjjsyy.cn

DOI: 10.12201/bmr.202603.00103

•  

  Abstract: Objective: To investigate the clinical efficacy of integrated traditional Chinese and Western medicine staging treatment strategy for granulomatous lobular mastitis (GLM) at different stages and its impact on patients quality of life. Methods: A retrospective analysis of 78 GLM patients (June 2022-June 2024) compared an integrated treatment group (n=40, tailored herbal medicine with low-dose hormones/surgery) versus a Western medicine group (n=38, hormones/surgery). Outcomes included clinical efficacy (total effective rate, recurrence rate, hormone duration, breast appearance satisfaction) and 36-item Short Form Health Survey (SF-36). Results: No statistically significant differences were observed between the two groups in the 6-month total effective rate or 6-month total cure rate (P>0.05). The 1-year total effective rate in the integrated group approached borderline significance (P=0.052), with an Absolute Risk Reduction (ARR) of 15.9%. The integrated group demonstrated superior 1-year total cure rate (70.0% vs. 47.4%) and 6-month recurrence rate (0.0% vs 15.8%) compared to the Western group (all P<0.05). Hormone use duration was reduced by 50% (P<0.05), postoperative breast satisfaction scores improved by 14.3%, and SF-36 total scores increased by 14.0%, showing significant correlations with hormone duration and breast preservation (P<0.01). Conclusions: The surgery-hormone therapy-Traditional Chinese Medicine Treatment staging protocol significantly enhances GLM outcomes by reducing recurrence, decreasing hormonal dependency, and improving quality of life. SF-36 proves valuable for comprehensive efficacy evaluation.

  Key words: Granulomatous lobular mastitis; Integrated traditional Chinese-Western medicine; Staging therapy; Quality of life; SF-36 scale

  Submit time: 23 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• CAO Xinyi, JIN Luoyao, LOU Yiyun. Analysis of Integrated Traditional Chinese and Western Medicine Treatment for Infertility Patients with Antiphospholipid Syndrome After Failed Artificial Insemination. 2026. doi: 10.12201/bmr.202603.00008

  SHEN Jianwu, BAO Yehua, ZHU Yueqiao, ZHU Jingyu. Integrated traditional Chinese and western medicine treatment of insomnia in hospitalized elderly patients. 2024. doi: 10.12201/bmr.202407.00059

  ZHANG Liying, Yin Yilong, GONG Hongxia, KOU Wei. Application of Integrated Traditional Chinese and Western Medicine and Mind Mapping in the Teaching of Human Parasitology. 2026. doi: 10.12201/bmr.202602.00087

  chenjiaying, YUJIANGTING, ZHOUYIMING, XULEILAI, GUXIDONG. Huang Tianjian1, Chen Jiaying1, Yu Jiangting1, Zhou Yiming1, Xu Leilai2, Gu Xidong21Zhejiang Chinese Medical University, Hangzhou 310053, China; 2The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China. 2026. doi: 10.12201/bmr.202601.00023

  YANGHUADI, LIHUI, ZHANGCHEN, MAOPEIYU. Meta-Analysis of the Efficacy and Safety of Traditional Chinese Medicine or Integrated Traditional Chinese and Western Medicine for Endometriosis. 2026. doi: 10.12201/bmr.202602.00053

  陈文会. Progress in Research on Pathogenesis and Treatment of Sequelae of Pelvic Inflammatory Disease from Integrated Traditional Chinese and Western Medicine Perspectives. 2026. doi: 10.12201/bmr.202602.00059

  Wang Huan, Ma Ying, Tian Jingnan, Lu Yi. Progress in the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Hypothyroidism from the Perspectives of Traditional Chinese and Western Medicine. 2025. doi: 10.12201/bmr.202505.00004

  zhuorui. . 2025. doi: 10.12201/bmr.202507.00041

  Research Progress on Integrated Traditional Chinese and Western Medicine for Chemotherapy-Induced Myelosuppression in Gastrointestinal Malignancies. 2025. doi: 10.12201/bmr.202506.00008

  guying. . 2025. doi: 10.12201/bmr.202506.00040

• ID	Submit time	Number	Download
  1	2025-10-20	10.12201/bmr.202603.00103V1	Download

• Public  Anonymous  To author only Submit Comments