Investigating the Pathological Closed-Loop Mechanism of Thrombus Organization—Cicatricial Contraction—Calcification Following Vascular Injury and Comprehensive Prevention Strategies

DOI: 10.12201/bmr.202603.00080

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  Abstract: Although thrombosis after vascular injury is an acute event, the subsequent organization, scar contraction and calcification are the root causes of chronic vascular stenosis, occlusion and restenosis. This study aims to construct a complete pathological logic chain from injury to calcification, reveal the synergistic stenosis mechanism of scar contraction and calcification, and propose a whole - process prevention and treatment system of traditional Chinese and Western medicine that takes into account "breaking blood, stabilizing thrombus, softening scars and preventing calcification". By combining the pathophysiology of Western medicine (thrombus organization, granulation tissue, scar contraction, vascular calcification) with the overall pathogenesis of traditional Chinese medicine (injury, blood stasis, intermingled phlegm and stasis, qi stagnation and collateral obstruction), a six - step closed - loop pathological chain of "injury → stasis → thrombosis → organization → contraction → calcification" is proposed, and a corresponding table of treatment methods of traditional Chinese and Western medicine at each stage is established. The research results show that the prevention of vascular calcification should not only focus on thrombolysis, but also pay attention to the repair and regulation at the organization stage and the soft - hard intervention before calcification; the whole - process therapy of traditional Chinese and Western medicine can effectively reverse vascular sclerosis, providing a new theoretical basis and treatment path for the prevention and treatment of vascular calcification.

  Key words: Vascular injury; Thrombus organization; Scar contraction; Vascular calcification; Integrated traditional Chinese and Western medicine prevention and treatment

  Submit time: 23 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-03-19	10.12201/bmr.202603.00080V1	Download

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