Advances and Therapeutic Strategies in Targeted Delivery of Traditional Chinese Medicine for Drug-Induced Liver Injury

Corresponding author: XinXing Wang, wxxemail@sina.cn

DOI: 10.12201/bmr.202601.00026

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  Abstract: Drug-induced liver injury (DILI) is a leading cause of acute liver failure. Current Western medical treatment primarily relies on drug discontinuation and supportive therapy, lacking efficient broad-spectrum detoxification agents, while the efficacy of N-acetylcysteine is significantly time-limited. Traditional Chinese medicine (TCM) demonstrates therapeutic potential through multi-target regulation, but its clinical translation is severely constrained by the complexity of its components and the risk of hepatotoxicity. In response to these challenges, this article systematically reviews recent advances in targeted delivery technologies: engineered modifications of nanocarriers enhance selective drug accumulation in the liver; the design of microenvironment-responsive drug release systems enables precise controlled release at the lesion site; and the use of extracellular vesicles (EVs) leverages their innate targeting capability and low immunogenicity to reduce systemic exposure risks. These strategies provide crucial technical support and a translational pathway for the effective and safe application of TCM in the treatment of DILI.

  Key words: Drug-induced liver injury; Traditional Chinese medicine; Targeted delivery technology

  Submit time: 9 January 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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