Research Advances in Clinical Treatment of Psoriasis: From Traditional Drugs to Biological Agents and Emerging Strategies

Corresponding author: zhangaili, fangjie812@sina.cn

DOI: 10.12201/bmr.202512.00051

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  Abstract: Psoriasis is a chronic, relapsing, inflammatory systemic disease mediated by T lymphocytes. Clinically, mild psoriasis can usually be controlled by topical medications, while moderate-to-severe cases require a combination of physical therapy and systemic treatment. Systemic drugs commonly used for the treatment of psoriasis include methotrexate, cyclosporine, retinoids, glucocorticoids, azathioprine, and biological agents. This article reviews the research advances in the pathogenesis of psoriasis, therapeutic drugs (including traditional drugs and biological agents), and novel drug delivery strategies, providing references for optimizing clinical treatment selection.

  Key words: Psoriasis; Biological agents; Therapy; Research advances

  Submit time: 18 December 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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