DOI：10.12201/bmr.202603.00080

Investigating the Pathological Closed-Loop Mechanism of Thrombus Organization—Cicatricial Contraction—Calcification Following Vascular Injury and Comprehensive Prevention Strategies

• 摘要：血管损伤后血栓形成虽为急性事件，但其后续机化、瘢痕收缩与钙化是导致血管慢性狭窄、闭塞及 再狭窄的根本原因。本研究旨在构建一条从形伤到钙化的完整病理逻辑链，揭示瘢痕收缩与钙化的 协同致窄机制，并提出兼顾“破血、稳栓、柔疤、防钙”的全程中西医防治体系。通过结合西医病理 生理学（血栓机化、肉芽组织、瘢痕收缩、血管钙化）与中医整体病机（形伤、血瘀、痰瘀互结、 气滞络阻）进行分析，提出了“形伤→瘀滞→血栓→机化→收缩→钙化”的六步闭环病理链，并建立了 对应各阶段的中西医治法对应表。研究结果表明，预防血管钙化不应仅关注溶栓，更应重视机化阶 段的修复调控与钙化前的软坚干预；中西医结合的全程疗法能有效逆转血管僵硬化，为血管钙化的 防治提供了新的理论依据与治疗路径。

  关键词： 血管损伤; 血栓机化; 瘢痕收缩; 血管钙化; 中西医结合防治

   

  Abstract: Although thrombosis after vascular injury is an acute event, the subsequent organization, scar contraction and calcification are the root causes of chronic vascular stenosis, occlusion and restenosis. This study aims to construct a complete pathological logic chain from injury to calcification, reveal the synergistic stenosis mechanism of scar contraction and calcification, and propose a whole - process prevention and treatment system of traditional Chinese and Western medicine that takes into account "breaking blood, stabilizing thrombus, softening scars and preventing calcification". By combining the pathophysiology of Western medicine (thrombus organization, granulation tissue, scar contraction, vascular calcification) with the overall pathogenesis of traditional Chinese medicine (injury, blood stasis, intermingled phlegm and stasis, qi stagnation and collateral obstruction), a six - step closed - loop pathological chain of "injury → stasis → thrombosis → organization → contraction → calcification" is proposed, and a corresponding table of treatment methods of traditional Chinese and Western medicine at each stage is established. The research results show that the prevention of vascular calcification should not only focus on thrombolysis, but also pay attention to the repair and regulation at the organization stage and the soft - hard intervention before calcification; the whole - process therapy of traditional Chinese and Western medicine can effectively reverse vascular sclerosis, providing a new theoretical basis and treatment path for the prevention and treatment of vascular calcification.

  Key words: Vascular injury; Thrombus organization; Scar contraction; Vascular calcification; Integrated traditional Chinese and Western medicine prevention and treatment

  提交时间：2026-03-23

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• 序号	提交日期	编号	操作
  1	2026-03-19	10.12201/bmr.202603.00080V1	下载

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