通讯作者: 吴远华, 957269860@qq.com

DOI：10.12201/bmr.202603.00065

Meta-analysis of Diversified Acupuncture and Medication Therapy for Vascular Dementia

• 摘要：摘 要 目的 系统探讨多元化针刺手段联合中药复方治疗血管性痴呆（Vascular Dementia,VaD）患者的综合疗效及安全性的影响。方法 通过检索Pubmed、Cochrane Library、万方数据、中国知网、维普数据库，筛选多元化针刺联合中药治疗VaD的临床研究，建立双盲文献筛选流程，并采用Cochrane偏倚风险评估工具进行质量评价，使用RevMan 5.4.1进行分析。结果 共纳入21篇文章，共1579例。系统评估VaD患者的认知功能与安全性指标。Meta分析结果显示：多元化针灸联合中药治疗在提高临床有效率、MMSE、ADL评分，降低中医证候积分、HIS、Hcy水平、炎性因子均优于常规西药组，且不良反应较少。且差异均具有统计学意义。结论 与单独应用西药治疗相比，多元化针药治疗VaD具有良好的疗效及安全性，并且可以调节患者的Hcy水平和血清中的多种炎性因子。

  关键词： 针刺；中药；血管性痴呆；Meta分析; ; ; 

   

  Abstract: Abstract Objective: To systematically explore the comprehensive efficacy and safety of diversified acupuncture methods combined with traditional Chinese medicine formulas in the treatment of vascular dementia (VaD). Methods: Clinical studies on the treatment of VaD with acupuncture combined with traditional Chinese medicine were retrieved from Pubmed, Cochrane Library, Wanfang Data, Chinese National Knowledge Infrastructure (CNKI), and VIP databases. A double-blind literature screening process was established, and the Cochrane bias risk assessment tool was used for quality evaluation. RevMan 5.4.1 was used for analysis. Results: A total of 21 articles were included, involving 1579 cases. The study systematically evaluated the cognitive function and safety indicators of patients with vascular dementia. The meta-analysis results showed that the combined treatment of diversified acupuncture and traditional Chinese medicine is superior to the conventional western medicine group in improving the clinical effective rate, MMSE and ADL scores, and reducing the TCM syndrome score, HIS, Hcy level and inflammatory factors. Moreover, it has fewer adverse reactions. and had fewer adverse reactions.Conclusion: Compared with the sole application of Western medicine, the diversified treatment combining acupuncture and medication for VaD exhibits favorable efficacy and safety. Moreover, it can regulate the Hcy level and various inflammatory factors in the serum of patients.Keywords: Acupuncture; Traditional Chinese Medicine; Vascular Dementia; Meta-analysis

  Key words: Acupuncture; Traditional Chinese Medicine; Vascular Dementia; Meta-analysis

  提交时间：2026-03-18

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-12-14	10.12201/bmr.202603.00065V1	下载

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