Research Progress on the Relationship between Vitamin D Deficiency and Recurrent MiscarriageZENG Biqi? Chen Haiyan

DOI: 10.12201/bmr.202603.00068

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  Abstract: Recurrent spontaneous abortion (RSA) is a common pregnancy complication that plagues women of childbearing age. In recent years, vitamin D (VD), as a steroid hormone with extensive immunomodulatory functions, has attracted increasing attention for its role in the field of reproductive health. A large number of studies have shown that vitamin D deficiency is closely associated with an increased risk of RSA. This article aims to review the potential immune and non-immune mechanisms by which vitamin D deficiency is involved in the pathogenesis of RSA. Vitamin D may be involved in the maintenance of pregnancy through multiple pathways, such as regulating the Th1/Th2 immune balance at the maternal-fetal interface, promoting the differentiation of regulatory T cells (Treg), inhibiting the excessive activation of natural killer (NK) cells, and affecting trophoblast function and placental angiogenesis. Meanwhile, vitamin D deficiency is often accompanied by conditions such as advanced age, obesity, and autoimmune abnormalities, which together increase the risk of RSA. This article systematically summarizes the current epidemiological evidence and potential mechanisms underlying the association between vitamin D and RSA, in order to provide a new perspective for clarifying the etiology of RSA and offer a theoretical basis for early screening and individualized intervention of RSA in clinical practice by assessing and correcting vitamin D deficiency.

  Key words: ? Vitamin D Deficiency; Recurrent Spontaneous Abortion; Risk Factors

  Submit time: 18 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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