DOI：10.12201/bmr.202603.00068

Research Progress on the Relationship between Vitamin D Deficiency and Recurrent MiscarriageZENG Biqi? Chen Haiyan

• 摘要：复发性流产(RSA)是困扰育龄女性的常见妊娠并发症。近年来,维生素D(VD)作为一种具有广泛免疫调节功能的甾体类激素,其在生殖健康领域的作用日益受到关注。大量研究表明,维生素D缺乏与RSA的发生风险增加密切相关。本文旨在综述维生素D缺乏参与RSA发病的潜在免疫及非免疫机制。维生素D可能通过调节母胎界面Th1/Th2免疫平衡、促进调节性T细胞(Treg)分化、抑制自然杀伤(NK)细胞过度活化、影响滋养细胞功能及胎盘血管生成等多个途径参与妊娠维持。同时,维生素D缺乏常与肥胖、自身免疫异常等状态并存,共同增加RSA风险。本文系统梳理了当前关于维生素D与RSA关联的流行病学证据及潜在机制,以期为阐明RSA的病因学提供新视角,并为临床中通过评估和纠正维生素D缺乏来进行RSA的早期筛查与个体化干预提供理论依据。

  关键词： 维生素D缺乏; 复发性流产; 危险因素

   

  Abstract: Recurrent spontaneous abortion (RSA) is a common pregnancy complication that plagues women of childbearing age. In recent years, vitamin D (VD), as a steroid hormone with extensive immunomodulatory functions, has attracted increasing attention for its role in the field of reproductive health. A large number of studies have shown that vitamin D deficiency is closely associated with an increased risk of RSA. This article aims to review the potential immune and non-immune mechanisms by which vitamin D deficiency is involved in the pathogenesis of RSA. Vitamin D may be involved in the maintenance of pregnancy through multiple pathways, such as regulating the Th1/Th2 immune balance at the maternal-fetal interface, promoting the differentiation of regulatory T cells (Treg), inhibiting the excessive activation of natural killer (NK) cells, and affecting trophoblast function and placental angiogenesis. Meanwhile, vitamin D deficiency is often accompanied by conditions such as advanced age, obesity, and autoimmune abnormalities, which together increase the risk of RSA. This article systematically summarizes the current epidemiological evidence and potential mechanisms underlying the association between vitamin D and RSA, in order to provide a new perspective for clarifying the etiology of RSA and offer a theoretical basis for early screening and individualized intervention of RSA in clinical practice by assessing and correcting vitamin D deficiency.

  Key words: ? Vitamin D Deficiency; Recurrent Spontaneous Abortion; Risk Factors

  提交时间：2026-03-18

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• 序号	提交日期	编号	操作
  1	2026-03-05	10.12201/bmr.202603.00068V1	下载

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