通讯作者: 冯志涛, 18606818121@163.com

DOI：10.12201/bmr.202610.00011

Clinical Study on the Regulating Stomach and Calming Mind Acupuncture Method in the Treatment of Chronic Insomnia of Spleen-stomach Disharmony Type

• 摘要：目的 观察调腑安神选穴法针刺治疗慢性失眠（脾胃不和型）的有效性和安全性。方法64例患者，随机分为调腑安神选穴组、常规选穴组，均治疗8周，比较2组患者匹兹堡睡眠指数量表(pittsburgh sleep quality index, PSQI）、中医症候量表、胃肠道症状评定量表(gastrointestinal symptom rating scale, GSRS)的降分值、脑内的神经递质五羟色胺( 5-hydroxytryptamine5-HT)、γ-氨基丁酸 (gamma-aminobutyric acid , GABA)、谷氨酸 (glutamic acid , Glu)、乙酰胆碱 (acetylcholine ,Ach)、去甲肾上腺素 (norepinephrine ,NE)、多巴胺 (dopamine,DA)分泌的实测值、临床有效率和不良反应的发生率。结果 2组患者治疗前PSQI、中医证候、GSRS的积分值、脑内神经递质含量值比较，差异不显著（P＞0.05）；8周治疗结束时2组PSQI、中医证候、GSRS的降分值，神经递质含量的变化及有效率的比较有差异（P＜0.05）。结论 调腑安神选穴法在改善睡眠质量、胃肠道症状、临床有效率、调节5-HT、GABA、Glu的分泌水平（由异常值趋向正常值作用等方面优于常规选穴法。

  关键词： 脑肠互动; 调腑安神; 慢性失眠; 脾胃不和型。; 

   

  Abstract: Objective To observe the efficacy and safety of the Regulating Stomach and Calming Mind Acupuncture Method in the treatment of chronic insomnia (spleen-stomach disharmony type),.MethodsSA total of 64 patients diagnosed and treated were divided into the Regulating Stomach and Calming Mind Prescription Group and the Conventional Prescription Group. Both groups received 8 weeks of treatment. The indicators for comparison between the two groups included the reduction scores of PSQI, Traditional Chinese Medicine Syndrome Scale and GSRS, the measured values of intracerebral neurotransmitter (5-HT, GABA, Glu, ACh, NE, DA) secretion, clinical effective rate and adverse reaction incidence.SResultsSThere was no statistically significant difference in baseline data including scale scores and neurotransmitter levels between the two groups before intervention (P>0.05). After 8 weeks of treatment, the intervention group showed significantly better performance in scale score reduction, neurotransmitter level regulation and clinical effective rate than the control group, with statistical difference (P<0.05).SConclusionSThe Regulating Stomach and Calming Mind Prescription is superior to the conventional prescription in improving sleep quality, relieving gastrointestinal functional symptoms, increasing clinical effective rate, and regulating the levels of intracerebral neurotransmitters 5-HT, GABA and Glu (shifting abnormal values towards the normal ranges).

  Key words: SBrain-Gut Interaction(BGI); Regulating Stomach and Calming Mind; Chronic insomnia; Spleen-stomach disharmony syndrome; Neurotransmitter.

  提交时间：2026-10-08

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• 序号	提交日期	编号	操作
  1	2026-09-24	10.12201/bmr.202610.00011V1	下载

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