通讯作者: 陈海东, 447874723@qq.com

DOI：10.12201/bmr.202603.00063

• 摘要：摘要：目的：基于美国国家健康与营养调查（National Health and Nutrition Examination Survey，NHANES）数据库，探讨14种常见膳食抗氧化剂与成人肌少症的关联性。方法：采用2011～2018年NHANES数据库数据进行分析。通过2次24小时膳食回顾法评估膳食抗氧化剂摄入水平；采用加权多变量逻辑回归分析线性关联，限制性立方样条模型探索非线性关系，结合亚组分析与交互作用检验明确异质性修饰因素。结果：线性关联：完全校正协变量后，镁（OR=0.9974，95% CI：0.9967～0.9981，P<0.001）、铜（OR=0.77，95% CI：0.63～0.95，P=0.019）、维生素 E（OR=0.97，95% CI：0.95～0.99，P=0.013）为肌少症的独立保护因素。非线性关联：α胡萝卜素（P=0.0384）、镁（P<0.001）、维生素C（P=0.0054）与肌少症存在显著非线性关系。亚组分析：α胡萝卜素与种族（P=0.0361）、教育水平（P=0.0007937）、家庭收入-贫困比（P=0.01938）间存在显著交互作用，在低收入、非西班牙裔、高中以上教育亚组中保护效应更强；维生素C与种族（P=0.018）存在交互作用，非西班牙裔人群中关联更显著。结论：膳食镁、铜、维生素E、α胡萝卜素、维生素C与肌少症呈负相关，其中镁、α胡萝卜素、维生素C存在阈值效应。在低收入组、非西班牙裔、教育水平高中以上组中α胡萝卜素保护作用更强。在非西班牙裔组中，维生素C具有更强的保护作用。

  关键词： 肌少症; 成年人; 横断面研究; 美国国家健康与营养调查(NHANES); 膳食抗氧化剂

   

  Abstract: Abstract:Objective:Based on the National Health and Nutrition Examination Survey (NHANES) database, this study investigated the associations between 14 common dietary antioxidants and sarcopenia in adults.Methods:A cross-sectional analysis was conducted using NHANES data from 2011 to 2018. Dietary antioxidant intake levels were assessed via two 24-hour dietary recalls. Weighted multivariate logistic regression analysis was applied to examine linear associations, while restricted cubic spline models were used to explore nonlinear relationships. Subgroup analysis and interaction test were performed to identify effect modifiers of heterogeneity.Results:Linear associations:After full covariate adjustment,magnesium(OR=0.9974,95%CI:0.9967～0.9981,P<0.001),copper(OR=0.77,95%CI:0.63～0.95,P=0.019),and vitamin E(OR=0.97,95%CI:0.95～0.99,P=0.013)were confirmed as independent protective factors against sarcopenia.Nonlinear associations:Significant nonlinear relationships were observed between α-carotene (P=0.0384),magnesium(P<0.001),vitamin C(P=0.0054)and sarcopenia.Subgroup analysis:α-carotene showed significant interactions with race(P=0.0361),educational level(P=0.0007937),and family income-poverty ratio(P=0.01938),with stronger protective effects in subgroups of low income,non-Hispanic ethnicity,and education above high school level.Vitamin C had a significant interaction with race(P=0.018),and its association with sarcopenia was more pronounced in non-Hispanic populations.Conclusion:Dietary magnesium,copper,vitamin E,α-carotene,and vitamin C are negatively correlated with sarcopenia,among which magnesium,α-carotene,and vitamin C exhibit threshold effects.The protective effect of α-carotene is more prominent in individuals with low income,non-Hispanic ethnicity, and education above high school level,while vitamin C exerts a stronger protective effect in non-Hispanic populations.

  Key words: Sarcopenia; Adults; Cross-sectional study; National Health and Nutrition Examination Survey (NHANES); Dietary antioxidants

  提交时间：2026-03-17

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• 序号	提交日期	编号	操作
  1	2026-02-23	10.12201/bmr.202603.00063V1	下载

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