通讯作者: 李爱仙, 346397618@qq.com

DOI：10.12201/bmr.202602.00067

Effect of sarcopenia on health outcomes in patients with acute decompensated heart failure: a Meta-analysis

• 摘要：目的　系统评价肌少症对急性失代偿性心力衰竭患者健康结局的影响。方法　计算机检索 PubMed、Web of Science、Embase、Cochrane Library、CBM、CNKI、万方及维普数据库，收集肌少症与急性失代偿性心力衰竭患者健康结局相关的文献，检索时限为建库至2025年11月18日。2名研究者依据预先制定的文献纳入与排除标准，独立开展文献筛选、数据提取，并完成对纳入研究的质量评价。采用RevMan 5.4和Stata 18.0软件进行统计分析。结果　最终纳入9篇文献。Meta分析结果显示，肌少症可显著增加急性失代偿性心力衰竭患者的全因死亡风险［HR=1.60，95% CI（1.40，1.83），P<0.00001］、心血管死亡风险［HR=1.75，95% CI（1.03，2.97），P=0.04］及复合不良结局风险［HR=2.67，95% CI（1.15，6.20），P=0.02］。亚组分析显示，非影像学评估的肌少症对心血管死亡无显著影响［HR=1.16，95% CI（0.75，1.79），P=0.51］，而影像学评估的肌少症会显著增加心血管死亡风险［HR=2.72，95% CI（1.79，4.14），P<0.00001］。结论　肌少症对急性失代偿性心力衰竭患者预后具有重要预测价值，临床应重视急性失代偿性心力衰竭患者的肌少症评估，并制定针对性干预措施，以降低不良健康结局发生风险。

  关键词： 急性失代偿性心力衰竭； 肌少症； 预后； Meta分析; ; ; 

   

  Abstract: Objective: To systematically evaluate the impact of sarcopenia on the health outcomes of patients with acute decompensated heart failure (ADHF). Methods: Computerized searches were performed in PubMed, Web of Science, Embase, Cochrane Library, CBM, CNKI, Wanfang Data, and VIP Database to collect studies on the association between sarcopenia and health outcomes in ADHF patients. The search period spanned from the establishment of each database to November 18, 2025. Two researchers independently screened the literature, extracted data, and assessed the methodological quality of the included studies in accordance with the inclusion and exclusion criteria. Statistical analyses were conducted using RevMan 5.4 and Stata 18.0 software. Results: A total of 9 studies were finally included. Meta-analysis results showed that sarcopenia significantly increased the risk of all-cause mortality HR=1.60, 95% CI (1.40, 1.83), P<0.00001, cardiovascular mortality HR=1.75, 95% CI (1.03, 2.97), P=0.04, and composite adverse outcomes HR=2.67, 95% CI (1.15, 6.20), P=0.02 in ADHF patients. Subgroup analysis revealed that non-imaging-assessed sarcopenia had no significant effect on cardiovascular mortality HR=1.16, 95% CI (0.75, 1.79), P=0.51, while imaging-assessed sarcopenia significantly increased the risk of cardiovascular mortality HR=2.72, 95% CI (1.79, 4.14), P<0.00001. Conclusion: Sarcopenia has important predictive value for the prognosis of ADHF patients. Clinical practice should attach importance to the assessment of sarcopenia in ADHF patients and develop targeted intervention measures to reduce the risk of adverse health outcomes.

  Key words: Acute decompensated heart failure; Sarcopenia; Prognosis; Meta-analysis

  提交时间：2026-02-14

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 田凤, 陈媛, 陈诗琪, 张榕祥, 朱晨阳. ERAS在心脏瓣膜病患者围手术期应用效果的Meta分析. 2024. doi: 10.12201/bmr.202410.00008

  薛琴丹. 健康素养在慢性心力衰竭患者症状负担与疾病不确定感间的调节效应分析. 2024. doi: 10.12201/bmr.202407.00062

  曾雯姝, 鲁兰莫, 杨怡, 刘孟莲, 王峻. 肌内效贴对脑卒中患者上肢功能和日常生活活动能力的网状Meta分析. 2024. doi: 10.12201/bmr.202410.00073

  赵家云. 基于循证的营养护理对重症心力衰竭患者疾病转归的影响. 2025. doi: 10.12201/bmr.202503.00018

  郑杰媚, 邱小芩, 韦吉思, 丘欣雨, 刘娜, 陈思帆. 慢性心力衰竭患者症状群的范围综述. 2025. doi: 10.12201/bmr.202501.00046

  吴晗, 廖才刚, 杨冯静. 温潜法分期治疗慢性心力衰竭探析. 2025. doi: 10.12201/bmr.202510.00061

  程欣雨, 向波, 刘可智, 梁雪梅. 口服避孕药的使用对抑郁症影响的Meta分析. 2026. doi: 10.12201/bmr.202601.00058

  王玥琳, 蒋运兰, 李乐, 陈红, 王镜, 张梦洁, 白小雨, 武森林. 中国精神分裂症住院患者并发代谢综合征危险因素的Meta分析. 2025. doi: 10.12201/bmr.202504.00071

  王楠, 王国蓉, 施雯停, 李清炉. 维持性血液透析患者皮肤瘙痒影响因素的系统评价和Meta分析. 2024. doi: 10.12201/bmr.202410.00043

  王可欣, 张少强. 不同功效组合的中药复方联合常规西药治疗冠心病合并抑郁的网状Meta 分析. 2024. doi: 10.12201/bmr.202410.00055

• 序号	提交日期	编号	操作
  1	2026-01-13	10.12201/bmr.202602.00067V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论