Meta-analysis and Trial Sequential Analysis of Traditional Chinese Medicine External Application for the Treatment of Infusion Phlebitis

Corresponding author: HE Yana, 909932870@qq.com

DOI: 10.12201/bmr.202509.00044

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  Abstract: Objective To systematically evaluate the clinical efficacy of external application of Chinese medicine compared to conventional Western medicine for treating infusion phlebitis. Methods We searched domestic and international databases for relevant randomized controlled trials (RCTs). A meta-analysis was performed using RevMan 5.4 software, and the quality of evidence was rated using TSA and GRADE tools. Results A total of 15 RCTs with 1435 patients were included. The meta-analysis showed that external application of Chinese medicine significantly increased the overall clinical effective rate and shortened the time to pain relief, pain disappearance, and resolution of redness and swelling. It also lowered VAS scores (P<0.05). The TSA results confirmed that the conclusion regarding the overall clinical effective rate is statistically reliable. The GRADE assessment, however, indicated that the overall quality of evidence was low. Conclusion The external application of Chinese medicine is generally superior to conventional Western medicine for treating infusion phlebitis, showing some clinical application potential. However, due to the low quality of evidence as assessed by GRADE, more high-quality, large-sample, multicenter studies are needed in the future to further validate these findings.

  Key words: Topical Chinese Medicine; Infusion phlebitis; Meta-analysis; GRADE; TSA

  Submit time: 18 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-08-04	bmr.202509.00044V1	Download

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