Efficacy and safety of Yuye decoction with metformin in type 2 diabetes mellitus: A meta-analysis

Corresponding author: PIAO Chun-li, pcl2013@sina.cn

DOI: 10.12201/bmr.202407.00066

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  Abstract: Objectives: To access the efficacy and safety of Yuye decoction with metformin in the treatment of type 2 diabetes mellitus (T2DM).Methods: A total of 8 databases including CNKI, SinoMed, Wanfang, VIP, Cochrane Library, PubMed, EMbase and Web of Science were retrieved for randomized controlled trial (RCT) of Yuye decoction in the treatment of T2DM. Cochrane handbook 5.3 was used to evaluate the quality of the included studies. RevMan 5.4.1 were employed to analyze data and test heterogeneity. The primary outcome was glycated hemoglobin A1c(HbA1c). Secondary outcomes include homeostatic model assessment for insulin resistance(HOMA-IR),total cholesterol(TC),clinical effective rate and adverse event rate.Results: A total of 10 RCTs were included in the final meta-analysis. The meta-analysis revealed that the improvements of HbA1c(MD=-0.92，95%CI-1.58,-0.26), HOMA-IR(MD=-0.14，95%CI-0.59,0.32),TC（MD=-0.83，95%CI-1.95,0.29）and clinical effective rate(OR=3.73，95%CI2.25,6.18) in the experimental group were better than those in the control group（P < 0.05）. There was no serious adverse effects being observed in both experimental group and control group. Conclusions: The combination of Yuye decoction and metformin could improve blood glucose and lipid profile as well as reduce insulin resistance, and no serious adverse reactions were observed yet. Further validation in the future is required through large-sample, multi-centered and high quality RCTs.

  Key words: Yuye decoction; type 2 diabetes mellitus; clinical trials; systematic review; meta-analysis

  Submit time: 29 July 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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