Risk factors for metabolic syndrome in hospitalized schizophrenia patients in China: a Meta-analysis

Corresponding author: JIANG Yunlan, 18980880152@163.com

DOI: 10.12201/bmr.202504.00071

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  Abstract: Objective To systematically evaluate the risk factors for metabolic syndrome in hospitalized patients with schizophrenia in China. Methods Relevant observational studies were retrieved from PubMed, Web of Science, Embase, The Cochrane Library, CINAHL, CBM, CNKI, Wanfang and VIP Database. The search period was from establishing the databases to January 12, 2025. Two researchers independently screened the literature, extracted data, and evaluated the quality of the studies. Meta-analysis was conducted using Stata 17.0 software. Results A total of 16 studies were included. The meta-analysis results show that age（OR=1.69, 95%CI: 1.43-2.01）, high BMI（OR=3.28, 95%CI: 1.45-7.42）, smoking history（OR=2.43, 95%CI: 1.85-3.20）, disease duration（OR=2.54, 95%CI: 1.85-3.48）, family history of metabolic syndrome（OR=2.65, 95%CI: 1.18-5.97）, history of diabetes（OR=3.47, 95%CI: 2.13-5.63）, history of hypertension（OR=4.61, 95%CI: 1.51-14.11）, use of clozapine（OR=2.35, 95%CI: 1.38-4.01）, use of olanzapine（OR=1.72, 95%CI: 1.03-2.88）, IL-6（OR=3.23, 95%CI: 1.11-9.38）, leptin（OR=1.54, 95%CI: 1.31-1.82）, TG level（OR=1.65, 95%CI: 1.02-2.68）, HDL level（OR=2.49, 95%CI: 1.49-4.17） were risk factors for metabolic syndrome in hospitalized patients with schizophrenia in China. Moderate exercise in spare time was a protective factor（OR=0.49, 95%CI: 0.28-0.85）. Conclusion Current studies show that there are many influencing factors for metabolic syndrome in hospitalized patients with schizophrenia in China. In the future, medical staff should prevent the occurrence of metabolic syndrome based on relevant high-risk factors and promote the long-term rehabilitation of patients with schizophrenia.

  Key words: Schizophrenia; Metabolic syndrome; China; Risk factors; Meta-analysis

  Submit time: 25 April 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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