Analysis on clinical features and prognostic factors in 68 adult hemophagocytic syndrome

Corresponding author: zhanglulu, Zhanglulu@hbmu.edu.cn

DOI: 10.12201/bmr.202502.00008

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  Abstract: Abstract Objective: To explore the clinical features and prognostic factors of adult hemophagocytic syndrome (HLH)Methods: The clinical data of 68 newly diagnosed patients with HLH who were hospitalrom December 2018 to December 2023 were retrospectively analyzed, and clinical features, survival, and prognostic factors of patients were analyzed.Results: The median age of 68 patients was 49 (17-75) years, the most common cause was infection, 40 cases (58.82%), and the most common clinical manifestation was fever, 63 cases (92.64%). Of the 68 patients, 12 (17.65%) died and the median survival time was 32 months. Cox univariate analysis showed that the prognosis of adult hemophagocytic syndrome was affected by SF, EBV infection, PLT count (< 20×109/L), age over 60 years old, APTT over 60s and other factors (P < 0.05). Multivariate Cox analysis showed that Epstein-Barr virus infection and PLT count (< 20×109/L) were independent prognostic factors of adult hemophagocytic syndrome (P < 0.05).Conclusion: The clinical manifestations of adult HLH are not typical, and the prognosis of adult HLH is affected by many factors. Ebv infection and PLT count (< 20×109/L) are independent risk factors for death.Key words: adult hemophagocytic syndrome; clinical features; prognostic analysis

  Key words: adult hemophagocytic syndrome; clinical features; prognostic analysis

  Submit time: 9 February 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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