[title missed]

Corresponding author: Liu Xiaoyu, 110263214@qq.com

DOI: 10.12201/bmr.202608.00025

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  Abstract: Abstract：Objective: Based on the gut-lung axis theory, to preliminarily explore the blocking effect of electroacupuncture on the progression from mild stroke-associated pneumonia (SAP) with phlegm-heat fu-excess syndrome to severe disease, and to analyze its efficacy in alleviating intestinal dysfunction and suppressing systemic inflammatory response.Methods: A single-center exploratory controlled pilot trial was conducted. A total of 100 mild SAP patients with PSI grade Ⅲ and phlegm-heat fu-excess syndrome admitted to our hospital were enrolled and randomly assigned to a control group (routine Western medicine treatment) and a treatment group (routine Western medicine combined with electroacupuncture), with 50 cases in each group. The primary outcome indicator was the severe transformation rate. Secondary indicators included the duration of antibiotic administration, 10-day recurrence rate, phlegm-heat fu-excess syndrome score and intestinal function recovery time. CPIS, CRP and PCT were detected before treatment, on the 3rd day, the 7th day and at the end of the treatment course to compare the clinical efficacy between the two groups.Results: The severe transformation rate was 8.0% in the treatment group, which was lower than 24.0% in the control group, with a statistically significant intergroup difference (P＜0.05). The treatment group had shorter antibiotic administration duration, faster recovery of TCM syndromes and intestinal function, and more obvious improvement in inflammatory markers compared with the control group (all P＜0.05). The 10-day recurrence rate was numerically lower in the treatment group without statistically significant difference (P=0.065).Conclusion: This pilot trial preliminarily suggests that electroacupuncture combined with Western medicine may reduce the risk of severe transformation and shorten the anti-infection course in patients with mild SAP. Its definite therapeutic effect needs to be verified by multi-center, large-sample formal RCTs.

  Key words: [keywords missed]

  Submit time: 12 August 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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