Exploration of TCM Treatment for Pulmonary Nodules Based on Lung-Intestine Correlation and Modern Immune Mechanisms

Corresponding author: sun shizhu, wws100171710@qq.com

DOI: 10.12201/bmr.202603.00116

•  

  Abstract: The theory of lung-intestine correlation originates from the statement The lung is internally connected with the large intestine recorded in Lingshu·Benshu (Spiritual Pivot·Primary Shu Points). Guided by the holistic concept of traditional Chinese medicine (TCM), this paper is based on the core pathogenesis of pulmonary nodules—qi stagnation, phlegm accumulation, and toxin aggregation. Combining with the modern immune mechanism of the Gut-Lung Axis, it traces the origin of the lung-intestine correlation theory, explores the regulatory mechanisms among intestinal flora, mucosal immunity, and the pulmonary immune microenvironment, and elaborates the treatment principle of simultaneous regulation of lung and intestine, detoxification, and resolving masses. This study reveals the scientific essence of the theory, provides new ideas for the syndrome differentiation and treatment of pulmonary nodules in TCM, and promotes the modern application of traditional TCM theories.

  Key words: Pulmonary nodules; Lung-intestine correlation; Gut-Lung Axis; Immune mechanism; TCM treatment

  Submit time: 26 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• LiuChengxin, ZhengAihua. Based on The Theory of Lung and Intestine Treatment, The Treatment Experience of Shengxue Tongbian Granules for Acute Lung Injury of Sepsis was explored*. 2025. doi: 10.12201/bmr.202509.00041

  Zhou Jie², Xiao Wei², Sun Zengtao. Understanding the Mechanism and Therapeutic Strategies of the Gut-Lung Axis in Chronic Obstructive Pulmonary Disease from the Perspective of. 2026. doi: 10.12201/bmr.202601.00005

  Wu chao. Research Progress in Cryoablation for Pulmonary Nodules. 2025. doi: 10.12201/bmr.202511.00093

  Zhou Heng, Zhou Qing, Wang Haozhu, Tian Xuefei. Treats Pulmonary Nodules Based on “Drink Often Surplus”. 2025. doi: 10.12201/bmr.202503.00084

  Zou Yang, Li Jia-ying. Experience of lung nodule treatment by Tongluo-dispersing method. 2024. doi: 10.12201/bmr.202411.00055

  ZHOU Tingjun, KUANG Wenjian, ZHENG Tuo, LUO Sheng. Application of Zhang Zhongjing’s Academic Thought of “Unsmooth Blood Circulation Results in Water Retention” in Pulmonary Nodules. 2025. doi: 10.12201/bmr.202501.00045

  zhoujianguo, hufangyun. Progress in CT AI diagnosis of pulmonary nodules. 2025. doi: 10.12201/bmr.202504.00068

  YOU Qing-hai. Construction of a TFF3-Related Prognostic Model for Lung Adenocarcinoma Based on Lasso-Cox Regression and Its Predictive Value for Immunotherapy. 2025. doi: 10.12201/bmr.202509.00054

  林治波, Zhang Zimin, WU Jianhua. Discussion on the Treatment of Knee Osteoarthritis from the Yangming System Combined with the Mechanism of the Gut-Joint Axis. 2026. doi: 10.12201/bmr.202603.00093

  liushunlin. The expression of CPNE1 and ZWILCH in the progression of lung adenocarcinoma and their correlation with prognosis. 2024. doi: 10.12201/bmr.202406.00030

• ID	Submit time	Number	Download
  1	2026-03-09	10.12201/bmr.202603.00116V1	Download

• Public  Anonymous  To author only Submit Comments