Analysis of risk factors of bronchopneumonia and lobar pneumonia caused by mycoplasma pneumoniae

Corresponding author: wumeihui, 1245668031@qq.com

DOI: 10.12201/bmr.202507.00035

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  Abstract: Objective To compare the laboratory indicators of bronchopneumonia caused by mycoplasma pneumoniae (MP) and lobar pneumonia in children, and to explore the risk factors of lobar pneumonia in children. Methods The data of 424 children diagnosed with pneumonia caused by MP infection in Weihai Maternal and Child Health Hospital of Shandong Province from July to October 2023 were collected and analyzed. They were divided into bronchopneumonia group (178 cases) and lobular pneumonia group (246 cases) according to chest radiographs. The differences in age, laboratory indicators and length of stay between the two groups were compared for statistical analysis. Results The age and hospitalization days of lobar pneumonia were significantly higher than those of bronchopneumonia (P<0.05). Lactate dehydrogenase (LDH), C-reactive protein (CRP), Adenosine deaminase (ADA), erythrocyte sedimentation rate (ESR) and D-dimer in children with lobar pneumonia were significantly higher than those in children with bronchopneumonia (P<0.05). The proportion of children with lobar pneumonia with mixed infection, pleural effusion, other organ damage, drug-resistant MP and bronchoscopy was higher than that of children with bronchopneumonia (P<0.05).Older children (OR=1.285, 95%CI: 1.165-1.418), LDH (OR=1.008, 95%CI: 1.004-1.012), ADA (OR=1.113, 95%CI: 1.057-1.173), CRP (OR=1.023, 95%CI: 1.002-1.045), ESR (OR=1.031, 95%CI: 1.009-1.054) and D-dimer (OR=4.500, 95%CI: 2.163-9.360) were risk factors for lobular pneumonia in children infected with MP. LDH, ADA, CRP, ESR, D-dimer all have certain predictive value for lobar pneumonia in children, and the area under the curve is respectively 0.612(95%CI:0.558-0.666,P<0.0001), 0.704(95%CI:0.654-0.753,P<0.0001), 0.659(95%CI:0.606-0.712,P<0.0001), 0.645(95%CI:0.592-0.697,P<0.0001), 0.679(95%CI:0.626-0.732,P<0.0001). When LDH, ADA, CRP, ESR and D-dimer were predicted together, the area under the curve was 0.793(95%CI:0.750-.837,P<0.0001). Conclusion There are obvious differences between bronchopneumonia caused by MP and lobar pneumonia in various laboratory indicators, leading to different prognosis of children. Comprehensive analysis of multiple indicators is conducive to the clinical differential diagnosis of the two types of pneumonia, and to guard against the occurrence of mycoplasma pneumoniae lobar pneumonia.

  Key words: Mycoplasma; pneumoniae, Bronchopneumonia, Lobar; pneumonia, Risk; factor

  Submit time: 11 July 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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