Clinical Study of Yiqi Tongfu Formula in Treating Sepsis-Induced Acute Gastrointestinal Injury with Qi Deficiency and Fu-Organ Excess Syndrome

Corresponding author: DENG Menghua, dmenghua@163.com

DOI: 10.12201/bmr.202607.00007

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  Abstract: Objective:To observe the efficacy of the Yiqi Tongfu Formula in treating sepsis-induced acute gastrointestinal injury (AGI) patients diagnosed with Qi deficiency and Fu organ excess syndrome. Methods: A total of 60 patients with sepsis-induced acute gastrointestinal injury (AGI) of Qi deficiency and Fu-organ excess syndrome, who were admitted to the Department of Critical Care Medicine of Foshan Hospital of Traditional Chinese Medicine from July 2023 to July 2024, were enrolled and randomly divided into a treatment group (n=30) and a control group (n =30) using a random number table method.The control group received standard conventional therapy, while the treatment group was supplemented with Yiqi Tongfu Formula. Both groups were treated continuously for 7 days. Parameters measured before and after treatment included: TCM syndrome scores, intra-abdominal pressure, abdominal circumference, AGI grade, gastrointestinal function score, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation(APACHE)-II score, and serum levels of diamine oxidase (DAO), D-lactate, intestinal fatty acid-binding protein (I-FABP), citrulline, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and procalcitonin (PCT). Clinical efficacy was statistically compared between the two groups. Results:After treatment, the improvement in TCM syndrome scores was significantly greater in the treatment group compared to the control group(P＜0.05). Intra-abdominal pressure, AGI grade, gastrointestinal function scores, SOFA score and APACHE-II score were significantly lower in the treatment group(P＜0.05). Serum levels of D-lactate, IL-6, TNF-α, and PCT were significantly reduced in the treatment group(P＜0.05). Conclusion:Yiqi Tongfu Formula can improve clinical efficacy in sepsis-induced AGI patients diagnosed with Qi deficiency and Fu organ excess syndrome,reduce intra-abdominal pressure, improve AGI grade and gastrointestinal function score, lower D-lactate, IL-6, TNF-α, and PCT levels, thereby ameliorating gastrointestinal motility disorder and intestinal permeability.

  Key words: Sepsis；Acute gastrointestinal injury；Gastrointestinal function；Outcome and treatment；Intestinal biomarkers; Inflammatory cytokines; ; ; 

  Submit time: 1 July 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-05-16	10.12201/bmr.202607.00007V1	Download

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