通讯作者: 邓梦华, dmenghua@163.com

DOI：10.12201/bmr.202607.00007

Clinical Study of Yiqi Tongfu Formula in Treating Sepsis-Induced Acute Gastrointestinal Injury with Qi Deficiency and Fu-Organ Excess Syndrome

• 摘要：目的 观察益气通腑方治疗脓毒症急性胃肠损伤（Acute Gastrointestinal Injury，AGI）气虚腑实证的疗效。方法 选取2023年7月至2024年7月于佛山市中医院重症医学科收治的60例脓毒症AGI气虚腑实证患者。按照随机数字表法分为治疗组（n=30）与对照组（n=30）。对照组患者采用西医常规治疗，治疗组患者在西医常规治疗基础上联合应用益气通腑方治疗，两组均连续治疗7天。两组治疗前后中医证候积分、腹内压、腹围、AGI分级、胃肠功能评分、序贯器官衰竭量表（Sequential Organ Failure Assessment，SOFA）评分、急性生理与慢性健康状况（Acute Physiology and Chronic Health Evaluation，APACHE）-Ⅱ评分，以及血清二胺氧化酶（diamine oxidase，DAO）、D乳酸、肠脂肪酸结合蛋白（intestinal fatty acid binding protein，I-FABP）、瓜氨酸、白细胞介素-6（Interleukin-6，IL-6）、肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）、降钙素原（Procalcitonin，PCT）等检验指标水平，并统计两组疗效。结果 治疗后，治疗组中医证候积分改善程度显著优于对照组（P＜0.05）；治疗组腹内压、AGI分级、胃肠功能评分、SOFA评分、APACHE-II评分均低于对照组（P＜0.05）；治疗组血清D-乳酸、IL-6、TNF-α及PCT水平显著降低（P＜0.05）。结论 益气通腑方能够提高脓毒症AGI气虚腑实证患者疗效，降低腹内压、改善AGI分级和胃肠功能评分，降低D-乳酸、IL-6、TNF-α及PCT水平，从而改善胃肠动力障碍与肠黏膜通透性。

  关键词： 脓毒症; 急性胃肠损伤; 胃肠功能; 肠道生物标志物; 炎症因子

   

  Abstract: Objective:To observe the efficacy of the Yiqi Tongfu Formula in treating sepsis-induced acute gastrointestinal injury (AGI) patients diagnosed with Qi deficiency and Fu organ excess syndrome. Methods: A total of 60 patients with sepsis-induced acute gastrointestinal injury (AGI) of Qi deficiency and Fu-organ excess syndrome, who were admitted to the Department of Critical Care Medicine of Foshan Hospital of Traditional Chinese Medicine from July 2023 to July 2024, were enrolled and randomly divided into a treatment group (n=30) and a control group (n =30) using a random number table method.The control group received standard conventional therapy, while the treatment group was supplemented with Yiqi Tongfu Formula. Both groups were treated continuously for 7 days. Parameters measured before and after treatment included: TCM syndrome scores, intra-abdominal pressure, abdominal circumference, AGI grade, gastrointestinal function score, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation(APACHE)-II score, and serum levels of diamine oxidase (DAO), D-lactate, intestinal fatty acid-binding protein (I-FABP), citrulline, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and procalcitonin (PCT). Clinical efficacy was statistically compared between the two groups. Results:After treatment, the improvement in TCM syndrome scores was significantly greater in the treatment group compared to the control group(P＜0.05). Intra-abdominal pressure, AGI grade, gastrointestinal function scores, SOFA score and APACHE-II score were significantly lower in the treatment group(P＜0.05). Serum levels of D-lactate, IL-6, TNF-α, and PCT were significantly reduced in the treatment group(P＜0.05). Conclusion:Yiqi Tongfu Formula can improve clinical efficacy in sepsis-induced AGI patients diagnosed with Qi deficiency and Fu organ excess syndrome,reduce intra-abdominal pressure, improve AGI grade and gastrointestinal function score, lower D-lactate, IL-6, TNF-α, and PCT levels, thereby ameliorating gastrointestinal motility disorder and intestinal permeability.

  Key words: Sepsis；Acute gastrointestinal injury；Gastrointestinal function；Outcome and treatment；Intestinal biomarkers; Inflammatory cytokines; ; ; 

  提交时间：2026-07-01

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• 序号	提交日期	编号	操作
  1	2026-05-16	10.12201/bmr.202607.00007V1	下载

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