朱满刚, 伍万, 刘振忠, 赵丽娟, 彭伟献. 基于“急性虚证理论”探讨四逆汤治疗脓毒症的应用价值. 2025. biomedRxiv.202507.00012
基于“急性虚证理论”探讨四逆汤治疗脓毒症的应用价值
通讯作者: 伍万, wuwantf@126.com
DOI:10.12201/bmr.202507.00012
Exploring the Application Value of Sini Decoction in Treating Sepsis Based on the Theory of Acute Deficiency Syndrome
Corresponding author: wuwan, wuwantf@126.com
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							    摘要:脓毒症是一种因宿主对感染反应失调而引发的危及生命的器官功能障碍,其病理机制复杂,且发病率和死亡率持续居高不下。近年来,中医的“急性虚证理论”为脓毒症的诊断和治疗提供了新的视角。本文结合中医理论与现代研究,系统探讨四逆汤在脓毒症治疗中的应用价值。研究表明,四逆汤通过调节炎症反应、改善免疫功能、保护器官功能等多重机制,显著改善脓毒症患者的预后,尤其在阳气暴脱型脓毒症中展现出显著的“补虚固脱”作用。本文从理论溯源、药理机制及临床实践三方面展开论述,以期为中西医结合治疗脓毒症提供科学依据。 Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, characterized by complex pathological mechanisms and persistently high morbidity and mortality rates. In recent years, the “Theory of Acute Deficiency Syndrome” in Traditional Chinese Medicine (TCM) has provided a new perspective for the diagnosis and treatment of sepsis. This paper systematically explores the application value of Sini Decoction in the treatment of sepsis by integrating TCM theory with modern research. Studies have shown that Sini Decoction significantly improves the prognosis of sepsis patients through multiple mechanisms, including regulating inflammatory responses, enhancing immune function, and protecting organ function. It particularly demonstrates notable efficacy in “tonifying deficiency and securing collapse”in sepsis cases characterized by sudden Yang Qi collapse. This paper discusses the theoretical origins, pharmacological mechanisms, and clinical practices of Sini Decoction, aiming to provide a scientific basis for the integrated treatment of sepsis using both TCM and Western medicine. Key words: Acute Deficiency Syndrome; Sepsis; Sini Decoction; Application Value提交时间:2025-07-04 版权声明:作者本人独立拥有该论文的版权,预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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								丁荔. 镁离子水平与脓毒症预后的研究现状. 2025. doi: 10.12201/bmr.202509.00008 颜林朗, 樊恒. 脓毒症急性肾损伤中脑啡肽原119-159的应用价值. 2024. doi: 10.12201/bmr.202408.00070 陈薪竹, 刘承鑫, 郑爱华★. 基于“肺肠同治”理论探析生血通便颗粒治疗脓毒症急性肺损伤经验*. 2025. doi: 10.12201/bmr.202509.00041 钱新阳, 王育民. pSOFA评分联合AGI分级评估脓毒症患儿预后的价值. 2024. doi: 10.12201/bmr.202411.00002 周思岑. 微小RNA在脓毒症相关急性肾损伤中的作用. 2024. doi: 10.12201/bmr.202410.00011 潘志豪, 胡家伟, 崔云, 吴家乐, 金童童, 应志康. 基于异病同治理论探讨柴胡加龙骨牡蛎汤在男科疾病中的应用. 2025. doi: 10.12201/bmr.202505.00041 赵士棋. 多模态监测在新生儿脓毒症相关性脑病的应用. 2025. doi: 10.12201/bmr.202501.00028 刘淑月, 秦超. 肠道微生态对老年脓毒症预后影响的研究进展. 2025. doi: 10.12201/bmr.202501.00041 王冰升, 石爱丽, 汪彬, 齐文豪, 董超群, 朱晓红, 史颜凯, 姚佳妮, 娄夏菁, 曹世华. 成人创伤患者脓毒症危险因素的Meta分析. 2024. doi: 10.12201/bmr.202412.00058 黄睿, 刘永芳. 陈帮明基于“虚气留滞”论治膜性肾病经验. 2025. doi: 10.12201/bmr.202509.00019 
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