The Role of Gastrointestinal Tumor Markers and Inflammatory Indicators in the Diagnosis and Treatment of Esophageal Cancer

Corresponding author: WANG Lei, max0126@126.com

DOI: 10.12201/bmr.202510.00034

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  Abstract: Esophageal cancer is the eighth most common type of cancer in the world and the sixth leading cause of cancer-related deaths. Because of its insidious and undetectable onset, it faces many complex difficulties and challenges in early prevention, diagnosis and treatment. At present, gastroscopy + pathological biopsy is the gold standard for the diagnosis of esophageal cancer, but it is not suitable as a screening examination for the population and is difficult to be popularized and applied because of its high cost, technical difficulty and invasiveness. Therefore, the search for one or a more convenient and effective diagnostic tool has become a research hotspot. Tumor markers and inflammatory markers, including proteins and nucleic acids, have gradually become a new direction in the research of esophageal cancer and other digestive tract tumors because of their simple, economical, convenient and reproducible detection methods. In recent years, significant progress has been made in the research on gastrointestinal tract-related tumor markers and inflammatory markers. New literature reports are constantly being published, which provide a new perspective for the early diagnosis and prognosis evaluation of esophageal cancer. The purpose of this article is to explore the application prospects of biomarkers suitable for early diagnosis and prognosis evaluation in the diagnosis and treatment of esophageal cancer, comprehensively analyze the latest research results, and review the research progress of biomarkers of esophageal cancer in recent years.

  Key words: esophageal cancer; tumor markers; Inflammatory markers; Diagnosis; Prognostic prediction

  Submit time: 21 October 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2025-08-17	10.12201/bmr.202510.00034V1	Download

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