Shenqi Fuzheng Injection: A Traditional Chinese Medicine Option for Adjunctive Treatment of Pneumonia

Corresponding author: wuqian, wuqian0422@163.com

DOI: 10.12201/bmr.202608.00021

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  Abstract: Pneumonia is a highly prevalent respiratory disease in clinical practice. In elderly patients, patients undergoing radiotherapy and chemotherapy for tumors, and critically ill patients, the core pathogenesis is often characterized by qi deficiency and deficiency of both the lung and spleen. These patients are therefore prone to prolonged inflammation, impaired immune function, compromised pulmonary function, and recurrent infections. Shenqi Fuzheng Injection, composed of Codonopsis pilosula and Astragalus membranaceus, exerts the therapeutic effects of replenishing qi and strengthening the body, invigorating the spleen and benefiting the lung, and reinforcing vital qi to eliminate pathogenic factors. Evidence from 34 clinical studies indicates that Shenqi Fuzheng Injection, as an adjuvant therapy for qi-deficiency-type pneumonia—including radiation pneumonitis, severe community-acquired pneumonia, senile pneumonia, immune checkpoint inhibitor-related pneumonitis, and lung cancer complicated by pneumonia—can significantly improve clinical efficacy, suppress inflammatory storms, regulate immune function, improve pulmonary ventilation and gas exchange, and reduce radiochemotherapy- and glucocorticoid-related adverse reactions, with a favorable safety profile. Based on the available evidence, this article systematically summarizes the prescription characteristics, material basis, pharmacological mechanisms, and clinical application value of Shenqi Fuzheng Injection, with the aim of providing a reference for the integrated traditional Chinese and Western medicine treatment of qi-deficiency-type pneumonia.

  Key words: Shenqi Fuzheng Injection; qi-deficiency-type pneumonia; integrated traditional Chinese and Western medicine; anti-inflammation; immunoregulation; pulmonary protection

  Submit time: 8 August 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-06-28	10.12201/bmr.202608.00021V1	Download

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