Determinations of HBP, IL-6, and PCT for the Application in patients with Chronic obstructive pulmonary disease

DOI: 10.12201/bmr.202604.00134

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  Abstract: Objective To investigate the determination of heparin-binding protein (HBP), interleukin-6 (IL-6), and procalcitonin (PCT) for application in patients with chronic obstructive pulmonary disease.Methods A retrospective analysis was conducted on 116 eligible patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), who were divided into a bacterial infection group (n=60) and a viral infection group (n=56) based on the causative pathogens. Additionally, 50 patients with stable COPD and 50 healthy individuals (normal control group) were included during the same period. Serum levels of HBP, IL-6 and PCT were measured in all subjects The levels of these biomarkers were compared among the four groups, and their diagnostic efficacy for AECOPD caused by bacterial infection was analyzed.A Spearman rank correlation analysis was conducted to examine the correlations between each indicator and disease severity. Furthermore, there levels of these indicators were compared in AECOPD patients before and after treatment. Results The levels of HBP and PCT in the bacterial infection group of AECOPD showed statistically significant differences when compared with the viral infection group of AECOPD, the stable COPD group, and the normal control group (P < 0.05). Similarly, the levels of IL-6 in the viral infection group of AECOPD exhibited statistically significant differences when compared with the stable COPD group and the normal control group (P < 0.05). The areas under the ROC curve (AUC) of HBP,IL-6 and DCP for diagnosing bacterial infection in AECOPD were 0.867, 0.789 and 0.923, respectively. Among these, PCT demonstrated the largest AUC, with an optimal cut-off value of 0.42 ng/ml, a sensitivity of 96.7%, and a specificity of 98.7%, indicating high diagnostic efficacy.All indicators showed a positive correlation with disease severity in the AECOPD bacterial infection group. In the bacterial infection group of AECOPD patients, the levels of HBP, IL-6, and PCT were significantly lower after treatment compared to before treatment (all P < 0.05). In the viral infection group of AECOPD patients, the levels of HBP and IL-6 decreased significantly after treatment compared to before treatment (P < 0.05). Conclusion The levels of HBP, IL-6, and PCT holds certain auxiliary diagnostic value for patients with acute exacerbation of chronic obstructive pulmonary disease and may serve as potential indicators of effective treatment. and is worthy of further study.

  Key words: Heparin binding protein; Interleukin-6; Procalcitonin; Chronic Obstructive Pulmonary Disease; Acute Exacerbation of Chronic Obstructive Pulmonary Disease

  Submit time: 20 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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