通讯作者: 何平, 434665369@qq.com

DOI：10.12201/bmr.202604.00134

Determinations of HBP, IL-6, and PCT for the Application in patients with Chronic obstructive pulmonary disease

• 摘要：目的 探讨肝素结合蛋白(HBP)、白细胞介素-6(IL-6)以及降钙素原(PCT)在慢性阻塞性肺疾病患者中的临床应用价值。方法 回顾性选取116例符合条件的急性期慢性阻塞性肺疾病患者(AECOPD),根据感染病原体不同,分为细菌感染组(60例)和病毒感染组(56例),收集同期的稳定期COPD患者和健康体检者(正常对照组)各50例。采集研究对象清晨空腹静脉血检测HBP、IL-6及PCT。比较4组研究对象各指标水平；分析以上指标对细菌感染导致的AECOPD患者的诊断效能；采用Spearman秩相关分析各指标与疾病严重程度的相关性；比较AECOPD患者治疗前后以上指标的血清水平。结果 AECOPD细菌感染组HBP、PCT浓度与AECOPD病毒感染组、COPD稳定期组,正常对照组比较,差异有统计学意义(P<0.05),AECOPD病毒感染组IL-6浓度与COPD稳定期组,正常对照组比较,差异有统计学意义(P<0.05)。HBP、IL-6及PCT诊断AECOPD细菌感染的AUC分别为0.867、0.789和0.923。其中PCT的AUC最大,最佳cut-off值为0.42ng/ml,敏感度为96.7%,特异度为98.7%,诊断效能较高；各指标均与AECOPD细菌感染组疾病严重程度呈正相关；细菌感染组AECOPD患者治疗后HBP、IL-6及PCT水平均较治疗前降低(均P＜0.05),病毒感染组AECOPD患者治疗后HBP、IL-6较治疗前降低(P＜0.05)。结论 HBP、IL-6及PCT的检测对急性期慢性阻塞性肺疾病患者的诊断有一定的辅助诊断价值,可能是疾病治疗有效的潜在指标,值得在临床上进一步的推广和研究。

  关键词： 肝素结合蛋白; 白细胞介素-6; 降钙素原; 慢性阻塞性肺疾病; 慢性阻塞性肺疾病急性加重

   

  Abstract: Objective To investigate the determination of heparin-binding protein (HBP), interleukin-6 (IL-6), and procalcitonin (PCT) for application in patients with chronic obstructive pulmonary disease.Methods A retrospective analysis was conducted on 116 eligible patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), who were divided into a bacterial infection group (n=60) and a viral infection group (n=56) based on the causative pathogens. Additionally, 50 patients with stable COPD and 50 healthy individuals (normal control group) were included during the same period. Serum levels of HBP, IL-6 and PCT were measured in all subjects The levels of these biomarkers were compared among the four groups, and their diagnostic efficacy for AECOPD caused by bacterial infection was analyzed.A Spearman rank correlation analysis was conducted to examine the correlations between each indicator and disease severity. Furthermore, there levels of these indicators were compared in AECOPD patients before and after treatment. Results The levels of HBP and PCT in the bacterial infection group of AECOPD showed statistically significant differences when compared with the viral infection group of AECOPD, the stable COPD group, and the normal control group (P < 0.05). Similarly, the levels of IL-6 in the viral infection group of AECOPD exhibited statistically significant differences when compared with the stable COPD group and the normal control group (P < 0.05). The areas under the ROC curve (AUC) of HBP,IL-6 and DCP for diagnosing bacterial infection in AECOPD were 0.867, 0.789 and 0.923, respectively. Among these, PCT demonstrated the largest AUC, with an optimal cut-off value of 0.42 ng/ml, a sensitivity of 96.7%, and a specificity of 98.7%, indicating high diagnostic efficacy.All indicators showed a positive correlation with disease severity in the AECOPD bacterial infection group. In the bacterial infection group of AECOPD patients, the levels of HBP, IL-6, and PCT were significantly lower after treatment compared to before treatment (all P < 0.05). In the viral infection group of AECOPD patients, the levels of HBP and IL-6 decreased significantly after treatment compared to before treatment (P < 0.05). Conclusion The levels of HBP, IL-6, and PCT holds certain auxiliary diagnostic value for patients with acute exacerbation of chronic obstructive pulmonary disease and may serve as potential indicators of effective treatment. and is worthy of further study.

  Key words: Heparin binding protein; Interleukin-6; Procalcitonin; Chronic Obstructive Pulmonary Disease; Acute Exacerbation of Chronic Obstructive Pulmonary Disease

  提交时间：2026-04-20

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• 序号	提交日期	编号	操作
  1	2026-03-20	10.12201/bmr.202604.00134V1	下载

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