Research Progress on the Application of Antibiotic Bone Cement in the Treatment of Diabetic Foot

Corresponding author: chaoshengwu, chaoshengwu@163.com

DOI: 10.12201/bmr.202604.00064

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  Abstract: Diabetic foot is one of the most serious chronic complications of diabetes, especially when combined with deep infection and osteomyelitis, it often leads to prolonged hospitalization, repeated surgeries, increased amputation rates and higher mortality risks. Due to factors such as lower limb ischemia, microvascular disease, neuropathy and bacterial biofilms, the efficacy of systemic antibiotic treatment is limited in some patients with diabetic foot infection (DFI). Antibiotic-loaded bone cement (ALBC) can continuously release high-concentration antibacterial drugs at the infection site, effectively fill dead spaces, provide local mechanical support and induce membrane formation, thus becoming an important auxiliary means in comprehensive treatment strategies. Existing studies suggest that on the basis of thorough debridement and systemic anti-infection treatment, ALBC can help improve the infection control rate of Wagner grade 2-4 DFI and diabetic foot osteomyelitis (DFO), shorten wound healing time, and increase the possibility of limb salvage and functional preservation in some patients. Overall, ALBC is more appropriately regarded as a phased intensification strategy connecting infection control and structural reconstruction, rather than a substitute for multidisciplinary management. Future prospective studies are still needed to clarify its precise positioning and application boundaries.

  Key words: Diabetes; diabetic foot infection; antibiotic-treated bone cement; osteomyelitis; local antibiotic delivery; multidisciplinary comprehensive treatment

  Submit time: 9 April 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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