通讯作者: 晁生武, chaoshengwu@163.com

DOI：10.12201/bmr.202604.00064

Research Progress on the Application of Antibiotic Bone Cement in the Treatment of Diabetic Foot

• 摘要：糖尿病足是糖尿病最严重的慢性并发症之一，尤其当合并深部感染和骨髓炎时，常导致长期住院、反复手术、截肢率升高及死亡风险增加。由于下肢缺血、微血管病变、神经病变及细菌生物被膜等因素，部分糖尿病足感染（diabetic foot infection，DFI）患者中系统抗生素治疗疗效受限。抗生素骨水泥（antibiotic-loaded bone cement，ALBC）可在感染灶内持续释放高浓度抗菌药物，同时有效填充死腔、提供局部力学支撑并诱导膜形成，从而成为综合治疗策略的重要辅助手段。现有研究提示，ALBC在充分清创与系统抗感染治疗基础上，有助于提高Wagner 2～4级DFI及糖尿病足骨髓炎（diabetic foot osteomyelitis，DFO）的感染控制率，缩短创面愈合时间，并在部分患者中提高保肢与功能保留可能性。总体而言，ALBC更适宜被视为连接感染控制与结构重建的阶段性强化策略，而非替代多学科管理。未来仍需前瞻性研究明确其精准定位与应用边界。

  关键词： 糖尿病；糖尿病足感染；抗生素骨水泥；骨髓炎；局部抗生素递送；多学科综合治疗; ; ; ; ; 

   

  Abstract: Diabetic foot is one of the most serious chronic complications of diabetes, especially when combined with deep infection and osteomyelitis, it often leads to prolonged hospitalization, repeated surgeries, increased amputation rates and higher mortality risks. Due to factors such as lower limb ischemia, microvascular disease, neuropathy and bacterial biofilms, the efficacy of systemic antibiotic treatment is limited in some patients with diabetic foot infection (DFI). Antibiotic-loaded bone cement (ALBC) can continuously release high-concentration antibacterial drugs at the infection site, effectively fill dead spaces, provide local mechanical support and induce membrane formation, thus becoming an important auxiliary means in comprehensive treatment strategies. Existing studies suggest that on the basis of thorough debridement and systemic anti-infection treatment, ALBC can help improve the infection control rate of Wagner grade 2-4 DFI and diabetic foot osteomyelitis (DFO), shorten wound healing time, and increase the possibility of limb salvage and functional preservation in some patients. Overall, ALBC is more appropriately regarded as a phased intensification strategy connecting infection control and structural reconstruction, rather than a substitute for multidisciplinary management. Future prospective studies are still needed to clarify its precise positioning and application boundaries.

  Key words: Diabetes; diabetic foot infection; antibiotic-treated bone cement; osteomyelitis; local antibiotic delivery; multidisciplinary comprehensive treatment

  提交时间：2026-04-09

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• 序号	提交日期	编号	操作
  1	2026-03-24	10.12201/bmr.202604.00064V1	下载

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