Promoting Effect of Bioactive Glass Doped with Different Elements on Odontogenic Differentiation

Corresponding author: GAOYAN, gaoyanbinyi@sina.com

DOI: 10.12201/bmr.202603.00025

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  Abstract: Abstract: Bioactive Glass (BG) has shown great potential in the regeneration of dental hard tissues due to its excellent biocompatibility, degradability and osteogenic properties. Dental Pulp Stem Cells (DPSCs) are considered the core seed cells for dental tissue engineering, as they possess ideal proliferation, migration, multi-directional differentiation and mineralization capabilities. A large number of in vivo and in vitro experiments have demonstrated that BG can promote the differentiation of DPSCs into odontoblasts and induce the formation of hydroxyapatite crystals with a structure similar to that of natural dental hard tissues. In recent years, studies have found that doping BG with elements such as strontium, zinc, magnesium and copper can improve its physical and chemical properties, regulate its degradation rate, and alter the profile of released elemental ions, thereby enhancing the ability of DPSCs to form dental hard tissues. This paper aims to review and summarize the promoting effect of modified BG doped with different elements on the odontogenic differentiation of DPSCs, and to explore the underlying mechanisms, providing a theoretical basis for the development of a new generation of bioactive materials.

  Key words: Bioactive glass; Element doping; Dental pulp stem cells; Odontogenic differentiation; tissue regeneration

  Submit time: 9 March 2026

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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  1	2026-01-24	10.12201/bmr.202603.00025V1	Download

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