A review of bionic bone tissue engineering porous scaffold design

Corresponding author: 黄歆旖, 3597323843@qq.com

DOI: 10.12201/bmr.202507.00028

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  Abstract: Bionic bone tissue engineering has gradually replaced the traditional bone grafting technology as the focus of bone defect treatment due to its advantages of inducing functional bone regeneration and modulating the stress barrier effect, etc. Bionic bone tissue engineering promotes bone regeneration from “structural replacement”to “functional reconstruction” through biomimetic design, biofabrication, and intelligent regulation. In order to design suitable bionic bone models and achieve structural optimization, this paper systematically compiles the latest research progress in the field of bionic bone tissue engineering, focusing on the application efficacy of different bionic models in bone tissue engineering, as well as the connection between structural bionic and functional bionic of bone tissue models. Numerous research results show that the use of Triply Periodic Minimal Surface (TPMS) topology optimization coupled with geometric feature reconstruction can significantly improve the bioactivity and mechanical properties of bone scaffolds, while the hierarchical sub-gradient modeling system provides an innovative solution for bone tissue engineering, which can effectively enhance the bio-integration efficiency of implants through the synergistic design of the internal and external structures. The bio-integration efficiency of the implant can be effectively improved through the synergistic design of internal and external structures. This multi-scale biomimetic design method not only breaks through the limitations of traditional manufacturing technology, but also lays a theoretical foundation for the development of personalized bone prostheses. How to construct idealized bone scaffolds with biomechanical fitness and multistage pore structure will be the focus of bone tissue engineering research in the future.

  Key words: bone tissue engineering; structural optimization; biomimetic function; three-period minimal surface (TPMS)

  Submit time: 8 July 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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