通讯作者: 高艳, gaoyanbinyi@sina.com

DOI：10.12201/bmr.202603.00025

Promoting Effect of Bioactive Glass Doped with Different Elements on Odontogenic Differentiation

• 摘要：生物活性玻璃(Bioactive Glass, BG)因其优异的生物相容性、可降解性和成骨性能在牙体硬组织再生领域颇受关注。牙髓干细胞(Dental Pulp Stem Cells, DPSCs)因其具有多向分化和促进矿化能力极适合作为牙组织工程的核心种子细胞,已有大量体内外实验证明BG不仅可以促进DPSCs成牙本质向分化,还可以促进牙本质基质矿化,形成与牙体硬组织结构相似的羟基磷灰石晶体。近年来研究发现,将锶、锌、镁、铜等元素掺杂入BG后,可改良其理化性能,调节BG的降解速率,改变元素离子释放谱等以达到促进DPSCs形成牙硬组织的效果。本文旨在回顾和总结不同元素掺杂的改良BG对成牙本质向分化促进作用,并总结探讨了其可能的作用机制,为开发新一代生物活性材料提供依据。

  关键词： 生物活性玻璃; 成牙本质分化; 牙髓干细胞; 元素掺杂; 组织工程

   

  Abstract: Abstract: Bioactive Glass (BG) has shown great potential in the regeneration of dental hard tissues due to its excellent biocompatibility, degradability and osteogenic properties. Dental Pulp Stem Cells (DPSCs) are considered the core seed cells for dental tissue engineering, as they possess ideal proliferation, migration, multi-directional differentiation and mineralization capabilities. A large number of in vivo and in vitro experiments have demonstrated that BG can promote the differentiation of DPSCs into odontoblasts and induce the formation of hydroxyapatite crystals with a structure similar to that of natural dental hard tissues. In recent years, studies have found that doping BG with elements such as strontium, zinc, magnesium and copper can improve its physical and chemical properties, regulate its degradation rate, and alter the profile of released elemental ions, thereby enhancing the ability of DPSCs to form dental hard tissues. This paper aims to review and summarize the promoting effect of modified BG doped with different elements on the odontogenic differentiation of DPSCs, and to explore the underlying mechanisms, providing a theoretical basis for the development of a new generation of bioactive materials.

  Key words: Bioactive glass; Element doping; Dental pulp stem cells; Odontogenic differentiation; tissue regeneration

  提交时间：2026-03-09

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• 序号	提交日期	编号	操作
  1	2026-01-24	10.12201/bmr.202603.00025V1	下载

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