通讯作者: 应长江, ycj321651@163.com

DOI：10.12201/bmr.202506.00038

Correlation between Serum DAPK1 and T-tau Protein Levels and Cognitive ImPairment in Patients with TyPe 2 Diabetes

• 摘要：目的：探讨血清死亡相关蛋白激酶1（Death-Associated Protein Kinase 1, DAPK1）和总Tau蛋白（Total Tau Protein,T-tau蛋白）水平与2型糖尿病（TyPe 2 Diabetes Mellitus, T2DM）患者认知功能障碍的关联，分析其危险因素，为早期识别和干预提供依据。方法：纳入2024年5月至2025年1月徐州医科大学附属医院内分泌科88例2型糖尿病认知功能障碍患者（认知功能障碍组）和90例无认知功能障碍患者（对照组），采用酶联免疫吸附法（Enzyme-Linked Immunosorbent Assay, ELISA）检测血清DAPK1和T-tau水平，采用Logistic回归分析危险因素。将认知功能障碍组按蒙特利尔认知评估量表（Montreal Cognitive Assessment, MoCA）评分分为重度（<10分，n=24）、中度（10-17分，n=31）、轻度（18-25分，n=33）三组，比较DAPK1和T-tau水平，用SPearman分析其与障碍严重程度的相关性。结果：两组患者性别、高血压、冠心病、脑梗死、体重指数、餐后1小时血糖、胰岛素、血脂、促甲状腺激素差异无统计学意义（P > 0.05）。认知功能障碍组年龄、病程、高脂血症比例、空腹血糖、糖化血红蛋白及餐后2小时血糖高于对照组，教育程度较低（P<0.05）。认知功能障碍组DAPK1和T-tau水平显著升高（P<0.05）。Logistic回归显示病程、糖化血红蛋白、DAPK1和T-tau为独立危险因素（P<0.05）。重度认知功能障碍组DAPK1和T-tau水平高于轻、中度认知功能障碍组（P<0.05）。SPearman分析表明DAPK1和T-tau与认知功能障碍严重程度正相关（均P<0.05）。结论：病程、糖化血红蛋白、DAPK1和T-tau是T2DM认知功能障碍的独立危险因素，其水平与障碍严重程度相关，可作为风险评估的潜在标志物。

  关键词： 2型糖尿病; 认知功能障碍; DAPK1; T-tau蛋白; 相关性; 

   

  Abstract: 【Objective】To investigate the association between serum levels of Death-Associated Protein Kinase 1 (DAPK1) and Total Tau Protein (T-tau) and cognitive imPairment in Patients with TyPe 2 Diabetes Mellitus (T2DM), analyze the risk factors, and Provide a basis for early identification and intervention.【Methods】 A total of 88 T2DM Patients with cognitive imPairment (cognitive imPairment grouP) and 90 T2DM Patients without cognitive imPairment (control grouP) were enrolled from the DePartment of Endocrinology, Affiliated HosPital of Xuzhou Medical University between May 2024 and January 2025. Serum DAPK1 and T-tau levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Risk factors were analyzed using Logistic regression analysis. The cognitive imPairment grouP was further stratified based on Montreal Cognitive Assessment (MoCA) scores into severe (<10 Points, n=24), moderate (10-17 Points, n=31), and mild (18-25 Points, n=33) subgrouPs. DAPK1 and T-tau levels were comPared among these subgrouPs, and their correlation with imPairment severity was assessed using SPearmans rank correlation analysis.【Methods】 ?There were no statistically significant differences (P > 0.05) between the two grouPs in terms of gender, hyPertension, coronary heart disease, cerebral infarction, body mass index (BMI), 1-hour PostPrandial blood glucose, insulin, blood liPids, or thyroid-stimulating hormone (TSH). ComPared to the control grouP, the cognitive imPairment grouP had significantly higher age, disease duration, ProPortion of hyPerliPidemia, fasting blood glucose, glycated hemoglobin (HbA1c), and 2-hour PostPrandial blood glucose, along with a lower education level (P < 0.05). Serum DAPK1 and T-tau levels were significantly elevated in the cognitive imPairment grouP (P < 0.05). Logistic regression analysis identified disease duration, HbA1c, DAPK1, and T-tau as indePendent risk factors for cognitive imPairment (P < 0.05). DAPK1 and T-tau levels were significantly higher in the severe cognitive imPairment subgrouP than in both the mild and moderate subgrouPs (P < 0.05). SPearmans correlation analysis demonstrated a significant Positive correlation between both DAPK1 and T-tau levels and the severity of cognitive imPairment (P < 0.05 for both).【Conclusion】?Disease duration, HbA1c, DAPK1, and T-tau are indePendent risk factors for cognitive imPairment in T2DM Patients. Their levels correlate Positively with the severity of imPairment and may serve as Potential biomarkers for risk assessment.

  Key words: Type 2 Diabetes Mellitus; Cognitive Impairment; DAPK1; T-tau Protein; Correlation Analysis; Risk Factors

  提交时间：2025-06-16

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• 序号	提交日期	编号	操作
  1	2025-03-27	bmr.202506.00038V1	下载

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