通讯作者: 张少强, tjzyzsq@163.com

DOI：10.12201/bmr.202410.00055

Network Meta-analysis of Different Efficacy Combinations of Traditional Chinese Medicine Compounds Combined With Conventional Western Medicines in the Treatment of Coronary Heart Disease Combined with Depression

• 摘要：目的:运用网状Meta分析评价不同功效组合的中药复方联合常规西药治疗冠心病合并抑郁的疗效差异。方法:通过计算机检索万方(Wanfang)、中国知网 (CNKI)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、Web of Science、PubMed、 EMbase、Cochrane Library,搜集建库至 2024 年 3 月 17 日中药复方联合常规西药治疗冠心病合并抑郁的随机对照试验(RCT),使用ROB 2.0软件评价文献质量和 Stata 16.0 软件进行网状 Meta 分析。结果:共纳入43篇RCTs,涉及8种功效组合方式。分析结果显示,清热安神类中药复方+常规西医临床疗效最高(SUCRA=78.7%),显著改善HAMD评分(83.2%)。理气类中药复方+常规西医治疗心绞痛效果明显(SUCRA=64.4%),改善中医证候疗效(72.9%),改善抑郁相关症状疗效(95.0%)。结论:和单独使用常规西药相比,联合应用中药复方效果更佳,其中理气为治疗该疾病的关键。然而,由于纳入文献质量差异较大,需要更加完善的试验来进一步验证。

  关键词： 功效组合; 中药复方; 冠心病; 抑郁; 网状Meta分析

   

  Abstract: : Objective:To evaluate the efficacy of different combinations of traditional Chinese medicine (TCM) prescriptions in combination with conventional western medicines in the treatment of coronary heart disease combined with depression using network meta-analysis. Method: Randomized controlled trials (RCTs) of Chinese herbal medicine combining with conventional western drugs for the treatment of coronary heart disease combined with depression up to March 17, 2024 were searched by computer on CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, EMbase, and Cochrane Library. Literature quality was evaluated using ROB 2.0 software and reticulated Meta-analysis was performed using Stata 16.0 software.Results: A total of 43 RCTs involving 8 efficacy combination modalities were included. The results of the analysis showed that the highest clinical efficacy was found in the heat-clearing and tranquilizing category of herbal compound + conventional western medicine (SUCRA = 78.7%), which significantly improved HAMD scores (83.2%). The effect of qi regulating type of Chinese medicine compound + conventional western medicine in treating angina pectoris was significant (SUCRA=64.4%), improved the efficacy of Chinese medicine symptoms (72.9%), and improved the efficacy of depression-related symptoms (95.0%). Conclusion: Compared with conventional Western medicines alone, the combined application of TCM compounding is more effective, in which regulating qi is the key to treating this disease. However, due to the wide variation in the quality of the included literature, more refined trials are needed for further validation.

  Key words: : Efficacy Combination; Herbal Compound; Coronary Heart Disease; Depression; Network Meta-analysis

  提交时间：2024-10-19

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2024-09-15	bmr.202410.00055V1	下载

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